An interesting recent research paper connecting alpha-synuclein, leaky gut, gut-brain axis and ... red blood cells!

[jeffreyn]

Perhaps some more pieces of the alpha-synuclein puzzle are slowly falling into place?

PNT article:

Mouse study sheds light on alpha-synuclein buildup in the gut

parkinsonsnewstoday.com/new...

Research paper (open access):

Erythrocytic α-Synuclein and the Gut Microbiome: Kindling of the Gut-Brain Axis in Parkinson's Disease

movementdisorders.onlinelib...

[Bolt_Upright]

I like this part: "Indeed, the microbiome showed some alterations in a mouse model of Parkinson’s, including an abundance of bacteria that produce a metabolite called butyrate. When mice were treated with butyrate for a month, the gut became less permeable, and RBC-EVs were not taken up as readily in the GI tract."