Good news coming from ANNOVIS BIO

[Farooqji]

biotuesdays.com/2023/06/20/...

[Michel0220]

Thank you very much for the post. This is one to follow closely.

[Sid44elosam]

it looks to me like one of the real potential vitres. Results should be known by year end. And it is only an extra pill to take ! Sounds great

[6daniparky]

Ottimo, chissà se potrebbe servire anche per chi è in uno stadio successivo?

[LeharLover62]

Thanks! I missed this and have been following this drug…I wish they’d hurry.

[WinnieThePoo]

I think there is ample possibility of disappointment. I realise most of us are hoping something genuinely new, and disease modifying has come along but there are a few "tells" this may not be the one.

First, after an episode of cringingly awful investor PR a few months ago, this is an announcement targetted at their investors. And what it says is the drug seems safe and they have easily recruited their target number of participants and will carry on with the trial as originally planned.

There was a lot of early excitement that in phase 2 it showed rapid and significant symptomatic relief. Posts on this forum have suggested the phase 3 trial talk has shifted to disease modification. But as I know with exanatide and SPARK, that is not easy to prove to the FDA's satisfaction. It would have a better chance of success if it could show clear symptomatic relief.

It has a 6 month double blind duration. SPARK and exanatide are both 2 years.

Primary outcomes were safety and tolerability, and updrs part 2 and 3 with an implication from the preamble about phase 2 results that this would be a statistically significant reduction in scores. Recent talk has been about an increase in scores slower than placebo. I have seen nothing suggesting they have discussed, never mind agreed this approach with the fda

[Farooqji in reply to WinnieThePoo]

Spot on!

[MBAnderson]

I have nothing to write home about after 2 months,

[gaga1958 in reply to MBAnderson]

I also have had no change good or bad at 2 months

[gaga1958]

I have not had any change, good or bad, after 2 months

[Delaraysbest in reply to gaga1958]

any update on this

[gaga1958 in reply to Delaraysbest]

No change.

[Delaraysbest in reply to gaga1958]

Could you be on the placebo?

[gaga1958 in reply to Delaraysbest]

I hope that’s the reason but no way to know

[Delaraysbest in reply to gaga1958]

Hope so too. Good luck