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Can someone point out the right kind of B1? Just found out about B1 applications for PD and feeling overwhelemed with the different kinds of B1 ( Mononitrate, hydrochloride, triphosphate , etc)
Reviewed several posts in this forum, and not quite clear
Appreciate the feedback
HCL according to Dr C
The two water soluble forms that have shown benefit are thiamine HCI at higher dose(25-4000 mg/day) and thiamine mononitrate in a lower dose dissolvable form at approximately 100 mg/day. Benfotiamine, a fat soluble form of B1 has not yet been reported to have the same effects yet, in this forum, as far as I know. Dr. Costantini felt that studies did not support benfotiamine as being able to get into the appropriate compartments in order to have similar effects to the water soluble forms.
Art
I have been taking high dose B1 thiamine HCL for about 5 years now ( 5x500mg) it appears to be keeping my Parkinson’s at bay.
do you take a 500 mg capsule at 5 different times?
I take 3 in the morning and 2 at lunch.
I tried taking the 4000 mg a day but my issue is the taste is just awful. Do they make a liquid version or a powdered version? That’s not so awful tasting?
I have taken 4000 mg/day of thiamine HCL from Vitacost in 500 mg capsules and in powder form. The capsules have no taste. The powder is extremely bitter and hard to take. Perhaps you should consider the thiamine mononitrate tabs that dissolve in your mouth. These seem to require a very significantly lower dose and while they don't taste good, they don't taste anywhere near as bad as the thiamine HCL powder.
Art
suggest you read “Parkinson’s and the B1 therapy”, available from Amazon.
The many different forms of B1 all work, you just need to find the right dose.
I generally use 250 mg to 1000 mg of thiamine hcl a day. Due to recent high bp I switched to the thiamine mononitrate, 300 mg which is not working out at all, Have you heard of anyone going much higher ?
Oral B1 hydrochloride doses have been used up to 4,000 mg with success.
I wouldn’t recommend mononitrate in large doses.
I would also recommend being consistent with your B1 dose so that you can give a dose a fair trial as you try to find the dose which stimulates symptom improvements
It seems very interesting that different forms seem to work better than others. If I was to guess I would say that HCl and TTFD both can work for PD - you've just got to figure out the dose. From what I've read Benfo has an entirely different mechanism. Its better than Hcl for raising general B1 levels but struggles to cross the blood brain barrier - whereas both HCl and TTFD achieve this through differing ways. Benfo, however, does seem to be very useful in treating diabetes and its associated symptoms in a way that neither HCl or TTFD can do.
The best case scenario would likely include both benfotiamine and one of the water soluble forms of thiamine such as thiamine hydrochloride or thiamine mononitrate for PwP.
Benfotiamine achieves at least two things that thiamine hydrochloride does not and is very relevant for PwP, it significantly reduces advanced glycation end products (AGEs) as well as its receptor (RAGE). In PD both are a problem and at elevated levels :
wur.nl/en/project/advanced-...
Here is a relevant quote :
' Increased levels of AGEs have been found in serum, brain, and cerebrospinal fluid of AD, PD, and MS patients, while in vitro studies show the cytotoxic effects of AGEs on neurons, the induction of neuroinflammation, and the disruption of the Blood-Brain Barrier (BBB) (Ahmed et al., 2003; Shuvaev et al., 2001; Takeuchi et al., 2000). '
Art
Thank you all that took the time to write back. I did purchase the book since i posted this message, and Hydrocloride seems best in the abscense of the sublingual mononitrate. Research continues. Looking into effective brands.
B1 trial
B1 therapy 
B1 therapy 
B1 Overdose
