Reactive Airways Dysfunction Syndrome RADS caused by L-dopa or inactive ingredients?

Reactive Airways Dysfunction Syndrome is described as a non-allergic condition, with asthma symptoms following exposure to high levels of highly irritating compound. If there is no history of respiratory disease, with abrupt onset of persistent asthma-like symptoms within minutes to hours of exposure to an irritant. This information is posted, by a pharma manufacturer as a possible occurrence when taking l-dopa. An 11 page safety sheet is on the internet. I wonder if it is the inactive ingredients that cause the problem.

Inactive ingredients in the tablets are Microcrystalline Cellulose, crospovidone, yellow #10 aluminum lake,hydroxpropyl cellulose, magnesium stearate and others in concentrations not available as they are proprietary.

A study “Crospovidone and Microcrystalline Cellulose:A Novel Description of Pharmaceutical Fillers in the Gastrointestinal Tract “ pubmed.ncbi.nim.nih.gov/280... summarizes that these two fillers are common, biologically inert, and they were found in the gastrointestinal tract, most frequently in the small bowel. 26 out of the 302 patients had identifiable amounts in their gastrointestinal tract.

These fillers are in a wide range of medications. PWP may take more tablets daily than most and typically weigh less than most. Taking the tablets may be unavoidable but knowing how to handle them may make them less harmful. They should not be crushed or split. They should be kept dry and shielded from light. People sensitive to dyes may want to coat their throats with a bite of ice cream or something to minimize contact with the esophagus.

[SilentEchoes]

"yellow #10 aluminum lake" looks like a big offender to me. Glad you posted this, a lot of folks on this forum might not recognize the cause of their own reactive airway dysfunction.

I didn't know you could get RADS from eating something. I associate it with inhalation exposure to chemicals or fumes, which is what happened to me.

RADS is chemical sensitivity from being over exposed to a chemical or group of chemicals. It's not asthma but feels like it, the difference is when you remove the noxious chemical the reaction goes away because it's not an immune system response and it doesn't respond to Albuterol. I've been tested. I have restrictive lung disease. There are many chemical odors that make me sick. Car exhaust is a big one. Going down the cleaning and laundry aisles in a store is torture. Then there are perfumes and body sprays, shampoo, and tobacco. The list is long. This isn't related to sense of smell, it's a systemic reaction in the autonomic nervous system. Speaking from my own experience. pubmed.ncbi.nlm.nih.gov/403...

A lot of references on this one: independentmedicalexperts.c...

SE

[Hidden in reply to SilentEchoes]

Thank you. This is the information I have been looking for.

[jrg54321]

Before I take an ldopa pill, I have a teaspoon of psyllium in 8 ounces of water. There was a study posted here about better outcomes of people taking psyllium with ldopa. It gives a good coating of the esophagus.

[jrg54321 in reply to jrg54321]

Here's the relevant post healthunlocked.com/cure-par...

[Hidden in reply to jrg54321]

Great idea. Thank you.

[LAJ12345]

the yellow colour is in the sinemet generic called Kinson which didn’t suit hubby.

Hubby now takes the madopar rapid tablet which is white so I assume it has no colourings at least.

[Hidden in reply to LAJ12345]

I appreciate this information. I will try to find one without color.

[LAJ12345 in reply to Hidden]

it still has other additives. I guess it’s a matter of trial and error. I dislike the billious blue of madopar capsules. How can something so blue be any good for you.

He often complains about stinging eyes and chemical taste in his mouth so I’m not sure what causes that.

[Hidden in reply to LAJ12345]

I notice a chemical taste after I brush my teeth. Tooth paste can be so harsh. I use a Waterpik after brushing.

Could the stinging be from dry eyes? Maybe try liquid tears or a wet washcloth compress for a few minutes. He sure is lucky to have you advocating for him.

[LAJ12345 in reply to Hidden]

thanks🙂.

He feels the chemical taste is coming out his skin. Yes it might be dry eyes. I have to wash them each day as his hands don’t work well.