From Patrik Brundin et al., another example of a bacterial infection (UTI) triggering a synucleinopathy (MSA).

[jeffreyn]

Research paper: Urinary tract infections trigger synucleinopathy via the innate immune response (2023)

link.springer.com/article/1...

Now, if they could just figure out why the alpha-synuclein proteins are not recycled correctly after they have played their role in the innate immune response, we could all go home already!

[chartist]

Interesting research and probably quite important. The article link below suggests that people with MSA are 90% more likely to have LUTS and UTIs are a common cause of LUTS.

parkinsonsblog.stanford.edu...

A relevant quote :

' Lower urinary tract symptoms are very common in MSA

Affect >90% of patients

May precede onset of other neurologic and orthostatic symptoms

May progress with time

Urine storage dysfunction and/or emptying dysfunction '

Art