Doxycycline antibiotic inhibits dopaminergic neurodegeneration through upregulation of axonal and synaptic proteins

link.springer.com/article/1...

Doxycycline (DOX) is a widely used antibiotic that is able to cross the blood–brain barrier. Several studies have shown its neuroprotective effect against neurodegeneration and have associated it with antioxidant, anti-apoptotic, and anti-inflammatory mechanisms. We have recently demonstrated that DOX mimics nerve growth factor (NGF) signaling in PC12 cells. However, the involvement of this mechanism in the neuroprotective effect of DOX is unknown.

more on Doxycycline

scienceofparkinsons.com/201...

[Todd-pw]

might just a coincidence but i was put on doxycycline by my dentist for a gum infection and my PD symptoms reduced almost straight away this i thought was probably due to the infection being killed off but once i stopped i noticed symptoms feeling worse. This is interesting altough i imagine long term use of antibbiotics is bad for you.

[Hidden in reply to Todd-pw]

scienceofparkinsons.com/201...