Summary: Targets to impede neurodegeneration.
1. Maintain adequate levels of neuronal NAD+.
2. Use Nicotinic Riboside 5 13
3. Avoid MNM 13
4. Block NAMPT
a. Melatonin inhibits NAMPT 16 17
b. Mangostin inhibits NAMPT 18–20
5. Block SARM1
a. berberine inhibits SARM1. 7
6. Block DLK
a. palmitoylation inhibitors (none identified)
b. block JNK downstream of DLK. 9
c. Melatonin down regulates JNK 21 22
///// References
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