I've been on Dr. Constantini's B1 HCL Protocol for about 6 months.
In the last couple of months, I gradually increased my daily dosage from 2,200 mg to 3,000mg.
At 3,000 mg, I noticed a lessening of constipation, but lately the toes on my left foot have had the tendency to curl sometimes.
Does that mean that I've gone over the optimal level of B1, or that I'm not taking enough? Should I take a break for a week and then decrease what I take (because I'm taking too much), or should I increase my dosage (because I'm not taking enough).