Lithium for Parkinson's Book Coming in October

[Bolt_Upright]

Update 7/15/22: I should have noted that the trial is using Lithium Aspartate, not Lithium Orotate. I e-mailed the doctor asking if Lithium Orotate would be as good and he said it should not make a difference. There were some rat studies linking Lithium Orotate with cancer so they went with Aspartate.

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So... I might be getting ahead of my skis here, but this is kind of curious:

Dr. Thomas Guttuso, Professor of Neurology, University at Buffalo is conducting the "Effects of Lithium Therapy on Blood-based Therapeutic Targets in Parkinson's Disease" trial clinicaltrials.gov/ct2/show... Estimated Study Completion Date : July 1, 2022

Dr. Thomas Guttuso, Professor of Neurology, University at Buffalo also has a book coming out.

The Book, "The Promise of Lithium: How an Over-the-Counter Supplement May Prevent and Slow Alzheimer's and Parkinson's disease", is currently scheduled to be available on Amazon in October 2022. promiseoflithium.com/

I'm not saying the trial was a success. I don't know. But... I am going to keep taking my 15 mg of Lithium Orotate.

Additional Reading:

Parkinson’s Disease: Potential Actions of Lithium by Targeting the WNT/β-Catenin Pathway, Oxidative Stress, Inflammation and Glutamatergic Pathway 2021 ncbi.nlm.nih.gov/pmc/articl...

Potential application of lithium in Parkinson's and other neurodegenerative diseases 2015 frontiersin.org/articles/10...

[Bolt_Upright]

I should say that I have not been diagnosed with PD. I have REM Sleep Behavior Disorder, which my doctor says will turn into PD. I also have a sore left shoulder, sore left left, and some involuntary muscle movements.

Also, I take a number of things. My shoulder does seem to finally be getting better and I have less muscle jerks, but who know. I hope to halt things where they are.

Here is a great video on low dose Lithium: youtu.be/J7VB6fOh9XE(Not working as expected?)

[Gioc in reply to Bolt_Upright]

In my opinion, adding lithium without medical supervision does not seem like a good idea to me, especially in conjunction with other antidepressants. Bipolar disorder is not PD. If you think have PD your medication is or will be levodopa.This is because the dopamine-producing tissue in the brain is partially lost in a Parkinson's patient. PD is more a matter of brain anatomy, given the injury, than a general imbalance of the chemical processes of the brain and the whole body.😜

[wifeofparky in reply to Gioc]

It is a much lower dose than what is prescribed for Bipolar disorders. I was at a symposium where Dr Guttuso presented his early study. He is seeking grants to expand the study to include more participants to validate the hypothesis and determine the lowest effective dose. Dr. Guttuso was my husband's MDS.

[LindaP50]

Thank you for this post. I don't recall reading anything on Lithium previously. Perhaps I wasn't interested at the time but this post caught my attention.

[wifeofparky in reply to LindaP50]

I attended his presentation on Lithium therapy. He has completed a lot of research on this and I look forward to further studies. Also his research study was done on PD patients not on animals.

[LindaP50]

I have a question. Why doe the doctor think REM will turn into PD?

[Bolt_Upright in reply to LindaP50]

Because statistically 50% of people diagnosed with RBD are diagnosed with PD within 5 years. 90% within 12 years.

[LindaP50 in reply to Bolt_Upright]

Do you know why?

[Bolt_Upright in reply to LindaP50]

Sorry, I don't know why. A lot of doctors believe RBD is an early symptom of PD (or LBD or MSA).

[MarionP in reply to Bolt_Upright]

Now that is an interesting statistic.

Any possibility of getting a source of actual numbers, samples, validity or any study along those lines of that claimed statistical association so people can have a look for themselves? Because when someone is claiming or using the term "statistically" then those statistics must be available somewhere for examination, or the person would not be able to say "statistically" in the first place.

[Bolt_Upright in reply to MarionP]

Just Google "REM Sleep Behavior Disorder Parkinson's" and the articles and statistics will come up. I would do it but I have already seen the papers and it depresses me to see them.

[MarionP in reply to Bolt_Upright]

It does, huh? Then this will pull you out of it.

science.org/content/article...

[Bolt_Upright in reply to MarionP]

Men lose Y chromosomes as they age. It may be harming their hearts

Study in mice is first to directly test health effects of losing male chromosome

?

[MarionP in reply to Bolt_Upright]

I just liked the headline title

[Gioc in reply to Bolt_Upright]

IMO se noi potessimo portare la vita media a 200 anni statisticamente il 100% delle persone contrarrebbero prima il PD poi l’alzheimer. Lo so che è una stupidaggine, ma la scrivo per farti riflettere su quanto sia lontano dal contesto reale questo “statisticamente “. Non lo traduco.

Traslation Addition

IMO if we could bring the average lifespan to 200 years , statistically 100% of people would contract PD first and then Alzheimer’s. I know it’s nonsense, but I write it to make you think about how far this “statistically” is from the real context.

Greetings from Italy

[LindaP50 in reply to Gioc]

Don't know what you posted but I do like the serene picture. 🙂

[Bolt_Upright in reply to LindaP50]

From Google Translate: IMO if we could statistically bring the average life to 200 years, 100% of people would contract first PD then Alzheimer's. I know it is nonsense, but I am writing it to make you reflect on how far this is "statistically" from the real context. I don't translate it.

[Bolt_Upright in reply to Gioc]

Grazie.

[bassofspades]

read.amazon.com/kp/embed?as...

My physician insisted that I read this book and start on Lithium as a therapy for PD. It has been nothing short of a miracle, as I have explained in numerous posts on this site. Feel free to search them, I have explained it to death! Any questions you have about the subject are answered in the book.

Read it!!!

[Bolt_Upright in reply to bassofspades]

One question please: Do you believe Lithium has stopped or slowed your progression? (You could also answer reversed).

[bassofspades in reply to Bolt_Upright]

Yes, it certainly helped. The biggest benefit I get from it is the total reversal in my chronic brain fog. The only supplements I take anymore are 15mg Lithium Oratate, sublingual B1 and a Magnesium supplement. And believe me, I tried nearly everything!

The other thing that helps me with PD is getting 8 hrs sleep a night, (for me, now with a CPAP) , and intermittent fasting. These things activate the body's natural garbage recycling action and clear unwanted proteins, from which PD related problems can stem from.

[Bolt_Upright in reply to bassofspades]

That is very cool that you are down to 3 supplements!

[MarionP in reply to bassofspades]

Another very interesting response.

[Ghmac in reply to bassofspades]

Where do you get sublingual B! and what dose do you take?

[Ghmac in reply to Ghmac]

What type of lithium do you take?

[bassofspades in reply to Ghmac]

oratate

[bassofspades in reply to Ghmac]

B1, 100mg I get it wherever its cheapest. usually amazon

[SilentEchoes]

Talk to me about your "muscle jerks" are they myoclonic seizure type? I have them in addition to fasciculations (two very different involuntary movements).

SE

[Bolt_Upright in reply to SilentEchoes]

I think I have both fasciculations and myoclonic jerks. Usually it is something like my foot moving at the ankle. I'd say it happens a couple times a day.

[MarionP]

very interesting study hypotheses. Will be looking forward to reading about it with some interest, as well as the upcoming publications. Doses indeed are quite quite low compared to uses of lithium in psychiatry. Of course the lithium preparations listed are controlled by prescription, and not the same thing at all as the one form of lithium available without a prescription, lithium Orotate.

Is this something you're going to be hanging on to and following?

[Bolt_Upright in reply to MarionP]

I started taking Lithium back in March. I plan to keep it up.

[JustJeff]

Really interesting particularly as it is found in exanatide which is in stage 3 trials

[JustJeff]

Hi Bolt where do you buy your 15 mg of Lithium Orotate from thanks

[Bolt_Upright in reply to JustJeff]

amazon.com/gp/product/B01FM...

[dvoranel]

Hi Bolt. Thank you so much for posting. How did you decide on dose of 15 mg rather than 5 or 20?

[Bolt_Upright in reply to dvoranel]

15 mg is the low dose in the trial.

[Jebbie12]

I’ve been taking 20 mg of lithium a day for 2 1/2 years, much less then the dosage for bipolar and similar disorders.. I am 13 years into my disease, and I am still going strong. I teach yoga once a week and exercise every day, including a 1 mile walk. Dr. Laura Mischley in Oregon is very knowledgeable about Lithium being used for Parkinson’s. She had my lithium levels tested, and they were very low. She has a wealth of information on her website. Google her name and check her out!

[JCRO in reply to Jebbie12]

Mischley’s MPH was on Lithium Orotate and PD. Her PhD on intra nasal Glutathione for PwP. I think that’s the right way round. She is working on a new project with MJFF on the benefits or otherwise of another supplement for PD (7/20222). I’ve also been taking 20mg of Lithium Orotate for 2.5 years.

[Boscoejean in reply to JCRO]

so what is the new supplement that Laurie Mischley is studying? Her Parkinson summer school is at Bastyr in Washington state or at least it has been there. (Kenmore, WA by Seattle) She is a naturopath and there are other naturopaths that have been advocating low dose lithium for some time. tahomaclinic.com/2010/05/li...

[JCRO in reply to Boscoejean]

Let me confirm. I “think” I know but don’t want to mislead.

[LindaP50 in reply to Boscoejean]

Oh, WOW! Sparked my interest even more when I read, "n addition to the benefits routinely mentioned, like controlling gout and relieving rashes caused by sebhorric dermatitis, lithium also has some great brain-boosting effects."

I get sebhorric keratosis and more so will definitely try this for me and getting brain-boosting effects is a plus. Will definitely purchase for me and my hubby (PWP). All my dermatologist recommended was a cream for "bumpy skin" which works OK not great.

Thanks for this post!!!

[Bolt_Upright in reply to LindaP50]

Thank you! I did not even notice the part that said it relived relieving rashes caused by sebhorric dermatitis!

[Bolt_Upright]

I should have noted that the trial is using Lithium Aspartate, not Lithium Orotate. I e-mailed the doctor asking if Lithium Orotate would be as good and he said it should not make a difference. There were some rat studies linking Lithium Orotate with cancer so they went with Aspartate.

[JayPwP]

Bolt, do you take LO before, after or with food?

[Bolt_Upright in reply to JayPwP]

I take it first thing in the morning. I may or may not eat soon after. I may not be doing this right.

[JayPwP in reply to Bolt_Upright]

How were you taking LO when you were also taking MB?

I am asking because I am expecting MB and LO to be delivered over the next two weeks.

[Bolt_Upright in reply to JayPwP]

I would have my MB first thing in the morning. Then my supplements soon after. I just try to get as much out of the way as possible first thing in the morning (which is about 10:30 AM for me)

[JayPwP in reply to Bolt_Upright]

Thanks Bolt

[JayPwP in reply to Bolt_Upright]

Dear All,

LO 5mg bottle received today. Would like to start from Saturday.

I should take it first thing in the morning on an empty stomach?

What signs and symptoms should I be looking out for? Any help with the dosing regiment?

Your views are solicited

[Discogs_discogs]

Here is the book referenced above:

amazon.com/gp/aw/d/15445295...