La Roche’s Prasinezumab (“Passadena”) Trial (BN42358)

[MAJ88]

Diagnosed with PD two years ago at the age of 48, I guess I’m one of the lucky few to be selected for Roche’s Prasinezumab trial, due to begin this fall.

Since my diagnosis, I don’t feel that my symptoms have gotten worse and I’m still able to keep the diagnosis to my inner circle (symptoms: slower “opening and closing” of my left index finger and thumb, than on the right hand and occasional slur and brain fog).

I’m very disciplined and try to work out 3x per week, go to the sauna and shower cold, while sticking to a mostly vegan, sugar- and gluten-free (as much as possible).

Furthermore, I am taking tons of supplements such as NADH, spermidine 2mg, 500mg vitamin B1 (thanks to you guys), 600mg Q10, NAC, etc. and, as of recently 1mg of metformin daily.

As the beginning of the trial is getting closer, I’m getting more worried about the trial’s potential negative effects. The active ingredient, Prasinezumab, is a monoclonal antibody and is supposed to eliminate alpha-synuclein.

My question to this amazing forum is, therefore, an open one: would you participate if you were me? Have you heard about other PD-studies with monoclonal antibodies and their results or side-effects? Any risks to watch out for? Positive reports welcome as well!

Questions over questions. Your input is highly appreciated. Thank you all!

[park_bear]

Here is a recent review of antibody therapy for Parkinson's. According to table 3, the safety record of such treatments has been good. Not much reported in the way of improvements but it is too early to tell:

ncbi.nlm.nih.gov/pmc/articl...

Additional comment:

2 milligrams of spermidine is unlikely to do anything, which is probably just as well, since it can be expected to be accompanied by the related spermine, which is adverse. See discussion in the comments here for more detail:

healthunlocked.com/cure-par...

[MAJ88 in reply to park_bear]

Thank you very much! Will look into it. 🙏🏻

[111BANDIT in reply to park_bear]

Absolutely

[Baron1]

Good choice and best of luck. From my research and readings, this particular drug has the most promise, based on earlier studies. Provided you get the dose and not a placebo, you should see benefits 12 months on.

[MAJ88]

Thank you for your encouraging words! There’s a 50% chance

[redhawk1]

Hello MAJ88. I have been a cohort in the Roche/Prothena clinical trial going on my 5th year. So far no adverse effects that I can connect with the trial.

Very hard to tell in my case whether or not this medication has slowed the progression of the disease. Glad to hear you have decided to participate in this trial. Feel free to message me if you have any questions.

[MAJ88 in reply to redhawk1]

Thank you redhawk1! Glad to hear you’re doing well. Will get in touch.

[MAJ88]

Thank you for your recommendations. I will check out the book, which really sounds interesting. With the device, however, I assume is a different story, as I’m based in Europe. Thanks again!

[Sydney75]

Too bad it is $30k, doubt insurance will cover for PD.