Interesting

[akgirlsrock]

Anyone familiar with this?

youtu.be/3R4Nhr5KauM(Not working as expected?)

[reedboat2]

Interesting but kinda confusing. He mentioned rodents, are they doing human studies? I’ll ask around. Thanks for posting- JG

[Bolt_Upright]

Plant product shows promise in mouse model of Parkinson’s Diseasehealth.ucdavis.edu/news/hea...

"The team found that a soluble epoxide hydrolase (sEH) inhibitor combined with kurarinone, a compound from the dried root of Sophora flavescens, reduced neuroinflammation in an animal model with Parkinson’s disease. The dried root, also known as kushen, has been used for hundreds of years in traditional Chinese medicines."

“We have known for a number of years that the soluble epoxide hydrolase inhibitors, now in human safety trials, are active in reducing the development of Parkinson’s disease in several rodent models,” Hammock said. “The evidence for this is quite strong, particularly based on the work of our long-term collaborator Kenji Hashimoto at Chiba University in Japan.”

[Bolt_Upright in reply to Bolt_Upright]

Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model 2022 pnas.org/doi/10.1073/pnas.2...

"Herein, we found that kurarinone, a unique natural product from Sophora flavescens, alleviated the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)–induced behavioral deficits and dopaminergic neurotoxicity, including the losses of neurotransmitters and tyrosine hydroxylase (TH)–positive cells (SN and striatum [STR]). Furthermore, kurarinone attenuated the MPTP-mediated neuroinflammation via suppressing the activation of microglia involved in the nuclear factor kappa B signaling pathway. The proteomics result of the solvent-induced protein precipitation and thermal proteome profiling suggest that the soluble epoxide hydrolase (sEH) enzyme, which is associated with the neuroinflammation of PD, is a promising target of kurarinone."

"In addition, sEH knockout (KO) attenuated the progression of PD, and sEH KO plus kurarinone did not further reduce the protection of PD in MPTP-induced PD mice. These findings suggest that kurarinone could be a potential natural candidate for the treatment of PD, possibly through sEH inhibition."

kurarinone

[Bolt_Upright in reply to Bolt_Upright]

So... kurarinone costs a fortune. Would Ku Shen suffice? Ku Shen is cheap. $30 for a pound of it at Walmart: walmart.com/ip/Nuherbs-Orga...

[Bolt_Upright in reply to Bolt_Upright]

Plant Product Shows Promise in Mouse Model of Parkinson’s Disease 2022 neurosciencenews.com/kushen...

This seems a bit misleading (or I am misunderstanding):

"Source: UC Davis

A natural product from the dried root of a pea-family plant, potentially combined with an enzyme inhibitor discovered in the laboratory of Professor Bruce Hammock at the University of California, Davis, may provide hope in alleviating neuroinflammation in Parkinson’s disease, a team of researchers from Dalian Medical University, China, and UC Davis announced Feb 21 in Proceedings of the National of Academy of Sciences. "

From the interview, and the details of this paper and other papers, I don't think the dried root product needs to be combined with the drug UC Davis created. It sounds like they both do the same thing.

[Bolt_Upright in reply to Bolt_Upright]

Sophora flavescens Aiton Decreases MPP+-Induced Mitochondrial Dysfunction in SH-SY5Y Cells 2018 ncbi.nlm.nih.gov/pmc/articl...

"The results of the present study showed that SF has neuroprotective effects against MPP+-induced cell death in SH-SY5Y cells. Specifically, SF suppressed MPP+-mediated ROS generation and collapse of mitochondrial membrane potential. Moreover, SF controlled apoptosis-related protein expression of Bcl-2 and Bax, caspase-3, release of cytochrome c and PD-related factors including Parkin, PINK1 and DJ-1 in SH-SY5Y cells. These results suggest that SF has the potential for use in neuroprotective therapeutics of PD."

[Hidden in reply to Bolt_Upright]

“The research used a model of Parkinson’s Disease in mice treated with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). Parkinson-like behaviors were significantly alleviated in mice treated with kurarinone. When tested in gene-modified mice with their sEH gene knocked out, kurarinone did not provide additional protection. “So does this mean that if someone PD is genetic and not due to toxic exposure, it won’t work? I don’t know how genetically modifying mice translates to any potential hypothesis of how it will effect humans.

?

[Bolt_Upright in reply to Hidden]

I "think" what they are saying is that kurarinone works on the soluble epoxide hydrolase (sEH) enzyme, and if they did the same experiment on mice without the soluble epoxide hydrolase (sEH) enzyme (sEH knockout mice), then the kurarinone did not do anything. I think they were using this information as evidence of the method of action.

[Bolt_Upright]

The 29+ Benefits Of Sophora Flavescens (Ku Shen) mybiohack.com/blog/sophora-...

Lots of great stuff, then this:

"Caveats

Sophora can act on cytochorome P450 (CYP450) enzymes and increase CYP2a, Cyp2b, and CYP3a. R R

This effect on liver enzymes may be gender specific, for example, male rodents taking sophora have an increased 7-ethoxyresorufin O-deethylation (EROD), 7-pentoxyresorufin O-dealkylation (PROD), coumarin hydroxylation, and nifedipine oxidation (NFO) activities, while females do not have any changes in coumarin hydroxylation and NFO activities. R

Ku shen contains kurarinone which can be toxic to the liver (reduces l-carnintine and PPAR-α pathway, ultimately leading to lipid accumulation and liver injury). R

Oxymatrine (in ku shen) at high doses (320mg/kg) may also be toxic to the liver by causing endoplasmic reticulum stress. R R

"

[Bolt_Upright]

Sophora Root (ku shen) acupuncturetoday.com/herbce...

[Bolt_Upright]

Sophora Flavescens Root (Ku Shen) chineseherbshealing.com/pro...

[Zardoz]

healthunlocked.com/cure-par...

healthunlocked.com/cure-par...

[Hidden]

Thank you for sharing this! I remember someone on here recently mentioned they use a tea with this. I think his username is House and the icon is an image of people walking. I will try and find him in hopes of finding out his tea source.

[Gibberesh]

In typical youtube fashion, the title of this video is misleading, so I followed up with additional research... Found this: "Their novel research, published in the current edition of the Proceedings of the National Academy of Sciences, shows that a soluble epoxide hydrolase (sEH) inhibitor and kurarinone, a compound from the dried root of Sophora flavescens, reduced neuroinflammation in an animal model with Parkinson’s disease. The dried root, also known as kushen, has been used for hundreds of years in traditional Chinese medicines." from: msn.com/en-us/health/medica...