Ferroptosis is a hot topic for Parkinsons research in 2022

New opinion piece reviews the association between iron deposition, glial activation, & neuronal death, explores how ferroptosis affects α-synuclein aggregation, & reviews clinical trials

cell.com/trends/molecular-m...

twitter.com/ScienceofPD/sta...

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QuoteFerroptosis is probably regulated by multiple pathways, including iron metabolism, oxidative stress, and cytotoxic amino acid metabolism (Figure 1). In addition, susceptibility to ferroptosis may also be affected by other pathways such as ferroptosis suppressor protein 1 (FSP1)–coenzyme Q10 (CoQ10) [15.].

Thought

Co Q 10 is a ferraptosis suppressor protein.

Sounds very important and validates precious assertions that CoQ10 is helpful

Deferoxamine is mentioned as an iron chelator used to reduce / stop ferroptisis

drugs.com/mtm/deferoxamine....

Quote

Moreover, the characteristics of ferroptosis induction are highly consistent with the pathological changes observed in PD patients, including increased iron content [4.,5.], lipid peroxidation [17., 18., 19.], and defects in the antioxidant system such as decreased levels of cystine/glutamate antiporter (xCT) [20.], glutathione (GSH) [21.], DJ-1 (that maintains cysteine and GSH biosynthesis) [16.], and CoQ10 [22.]. Furthermore, ferroptosis was observed in different PD cellular and animal models such as SH-SY5Y cells treated with MPP+ and 6-OHDA, and MPTP-lesioned mice [8., 9., 10.]. Furthermore, inhibition of ferroptosis by using ferrostatin-1 (Fer-1) can alleviate locomotor behavioral deficits and rescue tyrosine hydroxylase (TH) neuronal loss in MPTP-induced PD mice [23.].

Thought

Inhibit ferroptisis by using ferrostatin

What’s that?

Ferrostatin

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Quercitin inhibits iron absorption ?

Quercitin

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Iron chelator as

ncbi.nlm.nih.gov/labs/pmc/a...

[akgirlsrock]

Have you checked out Morley Robbins magnesium man , his research on iron , is interesting.

[Hidden in reply to akgirlsrock]

please link.

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therootcauseprotocol.com/ab...