FYI: Rosemary: ncbi.nlm.nih.gov/labs/pmc/a... - Cure Parkinson's
FYI: Rosemary
So... "Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer’s Disease, Parkinson’s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome"
More Nrf2 activation.
"Abstract
Rosemary (Rosmarinus officinalis [family Lamiaceae]), an herb of economic and gustatory repute, is employed in traditional medicines in many countries. Rosemary contains carnosic acid (CA) and carnosol (CS), abietane-type phenolic diterpenes, which account for most of its biological and pharmacological actions, although claims have also been made for contributions of another constituent, rosmarinic acid. This review focuses on the potential applications of CA and CS for Alzheimer’s disease (AD), Parkinson’s disease (PD), and coronavirus disease 2019 (COVID-19), in part via inhibition of the NLRP3 inflammasome. CA exerts antioxidant, anti-inflammatory, and neuroprotective effects via phase 2 enzyme induction initiated by activation of the KEAP1/NRF2 transcriptional pathway, which in turn attenuates NLRP3 activation. In addition, we propose that CA-related compounds may serve as therapeutics against the brain-related after-effects of SARS-CoV-2 infection, termed “long-COVID.” One factor that contributes to COVID-19 is cytokine storm emanating from macrophages as a result of unregulated inflammation in and around lung epithelial and endovascular cells. Additionally, neurological aftereffects such as anxiety and “brain fog” are becoming a major issue for both the pandemic and post-pandemic period. Many reports hold that unregulated NLRP3 inflammasome activation may potentially contribute to the severity of COVID-19 and its aftermath. It is therefore possible that suppression of NLRP3 inflammasome activity may prove efficacious against both acute lung disease and chronic neurological after-effects. Because CA has been shown to not only act systemically but also to penetrate the blood–brain barrier and reach the brain parenchyma to exert neuroprotective effects, we discuss the evidence that CA or rosemary extracts containing CA may represent an effective countermeasure against both acute and chronic pathological events initiated by SARS-CoV-2 infection as well as other chronic neurodegenerative diseases including AD and PD."
CA is a PED and is much safer than other electrophilic NRF2 activators because it is activated only at the site of oxidation and inflammation by ROS, which it then combats [36,37,38,39,40].
CA can potently suppress cytokine storm [98,99,100].
CA passes through the blood–brain barrier (BBB) with good bioavailability after oral administration [54].
CA inhibits activated microglia, in part, via inhibition of the NLRP3 inflammasome [18].
Rosemary (containing CA and CS) is recognized as a food additive in the U.S., EU, and Japan [4,5,6].
Rosemary (containing CA and CS) is already used clinically as a therapeutic against rheumatoid arthritis in Germany and is on the FDA “generally regarded as safe” (GRAS) list in the U.S. [103,104]. Moreover, CA manifests very few side effects at very high concentrations in two-species toxicity testing.
CA and CS have been shown to manifest neuroprotective effects in vivo in multiple models of AD and PD [64,65,66,67,68].
Because my supplement list is not long enough: Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders 2020 ncbi.nlm.nih.gov/labs/pmc/a...
"Conclusion
The present review demonstrates that the main ethnopharmacological uses (anti-spasm, analgesic, anti-inflammatory, anti-anxiety and memory-boosting) of rosemary have been validated by neuropharmacological investigations. By reviewing the previous literature, it is concluded that the most important components of rosemary which are medicinally and pharmacologically active are rosmarinic acid, carnosic acid, and the essential oil. These compounds can provide promising natural medicines in the treatment of the nervous system pathological conditions including anxiety, depression, Alzheimer’s disease, epilepsy, Parkinson’s disease, and withdrawal syndrome.
It is also noteworthy to mention that studies regarding herbal medicines should be taken into more consideration because the safety and efficacy of many herbal medicines are still unclear. Also, additional reliable trials are essential to evaluate the safety and efficacy of different constituents of rosemary in treating different nervous system disorders. Furthermore, the probable mechanisms of action and the potential antagonistic and synergistic properties of multi-component mixtures of rosemary need to be examined by the integration of physiological, pharmacological, bioavailability-centered, and pharmacokinetic methods. Prolonged and high dose usage of traditional formulations of rosemary and its active constituents should be avoided until more profound toxicity investigations become available. The new findings may expand the present therapeutic importance of rosemary and develop its future use in modern medicine. "
Bolt,
You want to add taste to your fish and other dishes? Add rosemary! It's a very common addition to a lot of foods in my country of birth.
An alternative is to rub rosemary oil on the bottom of your feet before you go to bed.
Interesting idea!
Well done House2!
I took a look at the literature and found about five cell culture studies of carnosol protecting dopaminergic cells against toxic insult. Every single one of them involved pretreatment prior to application of the toxic insult. This is not a valid model of a Parkinson's remedy. So as far as I know there is no valid evidence in favor of using rosemary for Parkinson's.
It crosses the blood brain barrier, and specifically modulates the NLRP3 inflammasome which is activated by a-synuclien which in turn causes chronic neuroinflammation thru microglia.
All of this looks reasonably important, as do the comments. I wonder what on earth it means?
"......it emerged in 2016 that more than one in ten inhabitants of the tiny..... Italian hamlet of Acciaroli in Salerno lived to be over 100 years old, .......After six months of research, the truth emerged. As lovers of tobacco, wine and food, there was nothing spartan about the Acciaroli way of life. Instead researchers identified rosemary as the secret ingredient added to the otherwise classically Mediterranean diet of this sleepy fishing town. Residents chew rosemary raw, toss it into virtually every dish and consume the local herb in large quantities.“They use rosemary on everything they cook,” said one of the researchers, Dr. Alan Maisel, a cardiologist and professor at the University of California, San Diego, School of Medicine.
And the quality of life for people in Acciaroli with nine or 10 decades behind them is high: virtually no cataracts, few bone fractures, excellent heart health and a low incidence of Alzheimer’s disease, Maisel said.
"Some studies have shown that rosemary can aid brain function, and the researchers think the variety grown in Acciaroli might have especially high concentrations of beneficial substances.
The older adults also demonstrate a robust sexual appetite, according to another researcher, Dr. Salvatore Di Somma, a professor of medicine at Sapienza University in Rome.
“At 95, they have brains more like someone who is 50, and at 50, you’re still thinking a lot about sex,” he said.
That's all for now I 'm going to make some rosemary tea!!!!!!!
Could a HERB be the secret to living to 100? Diet rich in rosemary linked to good health and long life expectancy in Italian village
Medical experts will examine pensioners living in Acciaroli near Salerno
They have remarkable record for living for longer but also free of disease
Population of a few thousand has about 300 people who are aged over 100
Mediterranean diet, fresh air and walking thought to influence long lives
Rosemary could be key to good health and longevity, according to medical experts who have looked at the diet of pensioners with a remarkable health record
