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Neurotrophic definition and neurotrophic ... - Cure Parkinson's
Neurotrophic definition and neurotrophic factors
Written by
WinnieThePoo
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How hard is it to start a new thread to discuss neurotrophic and neurotrophic factors?
John Pepper, you asked for a definition of neurotrophic.It is a word hardly ever used except as "neurotrophic factor"
It means "relating to the growth of nervous tissue."
"nerve repair" doesn't cover " help grow new healthy nerves"
"nerve replace" is completely wrong.
"nerve nurture" would be better
87 and he’s still working out with fast walking. Good on you JP. Keep on truckin’
Yes. So is my mother in law, and my friend (tennis partner) Graham. And neither of them has Parkinson’s disease either
But since this is a thread inspired by avoiding thread drift, I should note that it's not about John pepper
It's answering a question he asked about gdnf and neurotrophic factors and a definition of neurotrophic
Please stay on topic. If you want to propose John pepper for canonisation as a saint, please start your own thread
The best example we have, in my mind, of the the long term impacts of increased endogenous NFs (and whatever other good stuff is going on that we don't yet understand) as a result of intense exercise is Raphaekg
Happy for Karen to correct me, but the key takeaways are that it's hard work but worth doing. It's not a cure and I don't think there's evidence of dopaminergic neuron regrowth, or at least if they are regrowing they are doing so at a slower rate than the others are dieing. In other words, the condition still progresses. Which you'd expect, given that its PD we are talking about. If exercise completely stopped PD progression or caused net neuron regrowth, we wouldn't be sitting around discussing it.
Roger Barker in his webinar about stem cells, described it as fertiliser. It will make neurons grow better, but only if you have seeds or young plants to grow
Right. Bit different to having a mysterious disease torching everything in sight (albeit very slowly)
My dictionary tells me that 'Trophic' means 'concerned with nutritiion'. I suppose that if the glial cells are 'damaged' then giving them nutrition would help them to function better. But, I cannot think that dead cells can be revived with nutrition. The Mayo report indicates that high energy aerobic exercise insreases the number of glial cells, at least, that is what I get out of it.
John
GDNF Glial cell derived neurotrophic factor means the neurotrophic factor that is made by glial cells. It is one of a family of small proteins which nurture neurons, particularly dopamine neurons . Others are BDNF (brain derived neurotrophic factor) or abrineurin which is the one found to be increased in the spines of rats when exercising. It is encoded by the bdnf gene.
CDNF Cerebral dopamine neurotrophic factor is another one
All of these neurotrophic factors help neurons grow and thrive. Note neurotrophic is not neuroprotective
They are important for the growth and development of dopamine neurons in particular.
It is dopamine neurons which make dopamine. It is dopamine neurons which get destroyed / lost faster in parkinson's disease.
GDNF is a neurotrophic factor made by glial cells which helps look after dopamine neurons
It does not help look after glial cells
Glial cells have nothing to do with dopamine production (directly)
It is slightly surreal that I need to explain this to you given that you have been going on about gdnf since it's discovery in 1996
It was new and exciting then but not the silver bullet you misunderstood it to be
In my first book I mentioned the GDNF Trial donme in Bristol and have known about it since the late 90s. Glial cells do not produce dopamine they 'manage the production of dopamine'. If you think that glial cells have nothing to do with dopamine i assume you mean with the actual production of dopamine. Managing the dopamine production ia a lot to do with it!Knowing that GDNF is very important to PWPs , I wonder why nobody talks about it? Why have there not been any trials done on ' What can cause the brain to produce more dopamine?' When I ask questions at many international Parkinosn's Meetings I am met with silence! Either they do not know about it or they do not want to talk about it!
If other PWPs were to do exactly what I suggest then a lot more of them will stop needing to take any Pd medication, but HEY! Who wants that?
I've gotten botox injections in my left forearm and wrist to control tremor. I get them every three months. They lessen the tremor but don't stop them entirely. The trade-off is less grip strength when attempting chin-ups.
Kaypeeoh mate.It's lovely to hear from you but wtf has that got to do with gdnf or a definition of neurotrophic?
👀
I thought I was responding to a question about Botox. No idea how I ended up in this thread. 
