I'm Making Stuff Up Again: Lemon Sludge for PD

[Bolt_Upright]

I saw this video: Can Eating A Lemon Per Day Sky Rocket My Energy? youtu.be/u6iD6lD63aQ(Not working as expected?)

The video shows how you can blend whole lemons and have a tablespoon of lemon sludge in the morning and it lowers your PH and gives you energy and a bunch of good stuff, but it did not mention PD. So I went searching for evidence it might be good for PD too:

Potential Benefits of Nobiletin, A Citrus Flavonoid, against Alzheimer’s Disease and Parkinson’s Disease 2019 ncbi.nlm.nih.gov/labs/pmc/a... "Nobiletin, 3′,4′,5,6,7,8-hexamethoxyflavone, is a major component of polymethoxylated flavones in the peels of citrus fruits such as Citrus depressa, Citrus reticulata, Citrus sinensis, and Citrus limon":

Citrus depressa = sometimes called shiikuwasha, shequasar, Taiwan tangerine, Okinawa lime,[1] flat lemon, hirami lemon, or thin-skinned flat lemon, is a small, green citrus fruit rich in flavonoids and native to East Asia.

Citrus reticulata = Mandarin orange.

Citrus sinensis = includes the commonly cultivated sweet oranges, including blood oranges and navel oranges.

Citrus limon = Lemon!

"In this review, we summarized the beneficial effects of nobiletin against neurodegenerative diseases, such as AD and PD, in both animal models and cell culture systems. Nobiletin displays a wide range of beneficial effects against the features of AD and PD. However, further studies are needed to determine its primary molecular targets using proteomic-based approaches.

Regarding clinical application, a pilot clinical study was conducted to investigate the feasibility and safety of cotreatment with nobiletin-rich Citrus reticulata peel extract and donepezil in donepezil-preadministered AD patients [99]. In this study, six patients with mild-to-moderate AD were enrolled for treatment with nobiletin-rich Citrus reticulata peel extract. Five mild-to-moderate AD patients who were preadministered donepezil were enrolled for donepezil treatment alone as the control during the same period. Cognitive function was assessed with the mini-mental state examination (MMSE) and the Japanese version of the Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-J cog). One-year intervention with nobiletin-rich Citrus reticulata peel extract was suggested to prevent the progression of cognitive impairments in the patients, with no adverse events [99]. Further evidence from clinical trials is needed to establish the efficacy and safety of nobiletin as a useful strategy for the prevention and treatment of neurodegenerative diseases such as AD and PD."

I don't think I will get anywhere close to clinical doses of nobiletin from a tablespoon of lemon sludge every day, but I will get a bunch of antioxidants and flavanoids: Flavonoid Composition of Citrus Juices ncbi.nlm.nih.gov/labs/pmc/a...

You can also purchase nobiletin nootropicsdepot.com/nobilet... but for now I will stick with lemons.

Well look at this NMDA mention SilentEchoes Hidden onlinelibrary.wiley.com/doi... “Chinpi” in kampo medicine. The nobiletinrich C. reticulata peel extract (NChinpi) expectedly reversed N-methyl-D-aspartate (NMDA) receptor antagonist-induced dementia in mice, like nobiletin (in submission). Thus, in the present pilot clinical study, we tried to examine the

feasibility and safety of cotreatment with NChinpi and donepezil in donepezil-

preadministered AD patients, and tested the possibility that this Chinpi might be of benefit to …" I can't get past the paywall to read more.

[Hidden]

I have been doing something a little similar but the wimpy version. I use a cheese grater instead of zester for lemon and put a whole lemons worth in my food. Something I do not yet know is how this interacts with supplements and vitamins. I think the acidity would ruin some supplements and certainly probiotics. Do you know?

Do you eat ginger?

[Bolt_Upright in reply to Hidden]

There is nothing wimpy about cheese grating an entire lemon into your food

But I would point out that the Doctor says put the tablespoon of lemon sludge behind your teeth and swallow it. Best to keep it off your teeth.

I don't know how this would react to supplements, but I think it makes you more alkaline and less acidic. I not too concerned about it affecting my probiotics (I am having a Yakult a day at the moment).

I do not do Ginger, but if I had some dry ginger I would add some to my powder mix.

[Bolt_Upright]

Mmmm....

Lemon Sludge

[Smokeypurple]

Dr Mischley says 60% of people who have PD have reduced stomach acid. She says lemon juice is the nearest pH to stomach acid (cider vinegar not quite up there apparently).Better stomach acid = better food digestion (= more efficient meds?)

I also have wondered about whether it negatively affects anything else though. And the teeth thing.