PQQ combined with Ubiquinol - info and experience?

Hi all, I have found very little info on PQQ. I am wondering, anyone with experience or knowledge on this? Thank you!

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This is a screen shot from a video I’m listening to

Screen shot of video I’m listening to

[Bolt_Upright]

Interesting topic. Mitochondrial regulation by pyrroloquinoline quinone prevents rotenone-induced neurotoxicity in Parkinson's disease models 2018 pubmed.ncbi.nlm.nih.gov/302...

[Bolt_Upright in reply to Bolt_Upright]

Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson's disease model via AMPK activation 2021 pubmed.ncbi.nlm.nih.gov/328...

[Bolt_Upright in reply to Bolt_Upright]

PQQ & Parkinson’s Disease pqq.info/pqq-parkinsons-dis...

[bassofspades]

I took that combo for several months. (I tried a lot of experiments). It didn't have any noticable improvement on my symptoms of any kind. It didn't seem to hurt anything either, so if you, or a mouse effected by rotenone, want to give it a go then by all means, give it a try and let us know how you do. Everything works on those lucky mice. Humans are not usually as lucky beyond the beauty of the placebo effect.

The thing I want to know about rotenone mice is, does it cause genetic parkinson's with misfolded alpha synuclean proteins that clog up the works and choke dopaminergic neurons, or, does it directly kill the neurons in an amount limited by the exposure to the chemical? Thereby leaving the brain of the mice to allow itself to heal in ways that genetically malfunctioning humans cannot? This is my theory as to why things work in mice and not people. The Autophagy process is severely diminished in the genetically malfunctioning human brain cells, leading to a cascade of problems including weak mitochondrial systems, premature dopaminergic cell death and pruning of the interneuronal connections accross the various areas of the brain. All of these supplements would be most likely to help the mice speed their recovery, and I suspect it would be similar for a human that got parkinson's from toxin exposure, trauma, nutritional deficiency or some other cause of non genetic origin. But like I said, it probably won't hurt in most cases in safe quantities.

[bassofspades in reply to bassofspades]

And I think im going to post this as a new topic as well

[Hidden in reply to bassofspades]

Please do! I share your hypothesis! I believe that genetic PD can be triggered (kicked off) by toxin exposure, increases in inflammation, and factors that effect gene expression (epigenetics). One of my questions then is, in the case of genetic PD causing (or at least contributing) to the premature death of neurons, does that mean that senolytics are extra important? Or, are we in greater danger of overdoing senolytics? I used to think if something didn’t cross the BBB then I should discard it but given the vagus’ nerves and guts role in this, I am wondering if that is not the case?

[Despe in reply to Hidden]

Dr. John Bergman D.C.

youtube.com/watch?v=1_DBnv3...(Not working as expected?)

If you haven't heard of this doctor, please watch this video.

[bassofspades in reply to bassofspades]

I just read that ubiquinol doesn't really get up to the brain in large enough amounts to really make a difference in the oxidative stress .

[Bolt_Upright in reply to bassofspades]

Maybe it only has to reach the gut? (I have no idea and don't take ubiquinol. I just think part of the answer may be in treating the gut [but I might be that guy looking for my keys in the kitchen when I lost them in the bedroom because the light is better in the kitchen]).

[Despe in reply to bassofspades]

Love your insight, Bass. Can we transform to mice?

[bassofspades in reply to Despe]

Sure, just go to Disney world and put on some "ears"!

Hey I just got one of my brilliant ideas! We could get some mouse DNA, see? And infuse it into the brains....

🐭🧀

[Despe in reply to bassofspades]

Never thought of that, brilliant.

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Bass, I just posted a report that briefly discusses proteins role in PD. The kind and volume of protein can contribute to inflammation via ROS (reactive oxygen species). But it should also be mentioned that the same applies for many types of fats/oils. Some are extremely pro-inflammatory. I firmly believe that being in ketosis (not constantly) can reduce symptoms and slow decline but the means of getting in to ketosis is nuanced. Kia is right that the overconsumption of protein can make symptoms worse. This is largely but I don’t think entirely due to the pro-inflammatory nature of a high protein diet. But a high carb diet is also detrimental. Which is why I believe a low carb, low protein, low sugar (including natural sugars) diet rich in healthy fats and veges is our best dietary course.

[Kia17 in reply to Hidden]

High protein diet can raise insulin level almost the same as sugar does.

Dietary proteins have an insulinotropic effect and thus promote insulin secretion, which indeed leads to enhanced glucose clearance from the blood. In the long term, however, a high dietary protein intake is associated with an increased risk of type 2 diabetes.

nature.com/articles/ejcn201....

[Rhyothemis]

I've noticed pinker gums and nailbeds with PQQ + ubiquinol (or MitoQ, a bit pricy these days) - which perhaps means better microcirculation. I get the same effect from pomegranate extract (contains ellagic acid which converts to urolithin A if you have the right gut bacteria) + ubiquinol.

{ I don't have PD. }

[Hidden in reply to Rhyothemis]

Very interesting. Pomegranate extract, I wonder if that’s better than pomegranate powder? I use the one in the photo I’m including. I rotate between that and beet powder and cranberry powder. I don’t understand the tie in with ubiquinol. I need to learn about that. Hadn’t heard of MitoQ. Thank you for introducing me to it.

Pomegranate powder

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Can someone please recommend a Mito-Q (ubiquinol PQQ) supplement? I’m currently using Jarrow Ubiquinol and have ordered Double Wood PQQ. But I’ve heard that Mito-Q might be better.