Hi all

[Justme4]

I'm an looking at cutting down my rytary as i don't feel it does much for me. I've tried to get my ms to change my meds but she doesn't it she just throws' another rytary at me i currently take 48,75-1953 times a day and neupro 4mg patch daily i did wean myself down to just 2 rytary a day before so i dint think i will have any problems doing it again, I'm wanting to add \try mucana, i do well with inbrija my question is what brand to use and dosage ?As well as anyonee3les been successful in coming off rytary?

[Hmop]

Hi all, I have the same problem. I would like to stop Pramipexole. Feel very bad and no results. No help from the neurologist. Can anyone advice me how to stop it? And how to dosage Mucina and which kind? Thanks!

[park_bear in reply to Hmop]

Pramipexole must be tapered:

medicines.org.uk/emc/produc...

"Treatment discontinuation

Abrupt discontinuation of dopaminergic therapy can lead to the development of a neuroleptic malignant syndrome or a dopamine agonist withdrawal syndrome. Pramipexole should be tapered off at a rate of 0.54 mg of base (0.75 mg of salt) per day until the daily dose has been reduced to 0.54 mg of base (0.75 mg of salt). Thereafter the dose should be reduced by 0.264 mg of base (0.375 mg of salt) per day (see section 4.4). "

[Astra7 in reply to Hmop]

I also don’t think the pramipexole does anything but if took such a process to get to this dose that I’m sure going the other way is going to be a pain.Why were you prescribed it? It was meant to help we stop freezing and falling while playing tennis, but if didn’t help.☹️

[Hmop in reply to Astra7]

Yes Prescribed in Bulgaria.

[Jeaner73 in reply to Hmop]

Pramipexole weaning for me from 1.5 mg a day.

Diagnosed in 2011. Started Pramipexole in 2012

Went down to half 9/15/21 - .375 2x day

9/28/21 morning dose .1875 afternoon .375.

10/5/21 .1875 morning .1875 afternoon

10/16/21 .1875 be afternoon only

10/24/21 .1875

Stopped end of October 2021

I was taking sinemit 25/100 3x daily

Sinemit 25/100 CR 2x daily at night

With the Pramipexole 1.5mg

Weaning I had muscle and joint pain, trouble sleeping. I felt like I was off all the time which I rarely felt on pramipexole. My neurologist gave me a plan to wean for a month, then start Entacapone. I started the Entacapone while weaning because I felt such a dopamine hole. I stopped and after a couple days each day got worse. I felt like I was heading into a depression I didn’t have time for. After a week I took 3 .1875 doses over a couple days then contacted my neurologist.

Started taking 1 carbidopa/levodopa 25/100, entacapone 200mg 4 x daily

2 carbidopa/levodopa 25/100 CR 2 x daily

I was able to stop at the end of October. After a couple weeks my head cleared and I’m sleeping better, joint pain is gone, no more constipation, and realized I could control food intake. What I don’t like is I’m so close in dosing to wearing off every 4 hours I have to take a c/l CR at 10pm and 3am.

I saw my neurologist today and I may try Rytary.

[JohnPepper]

Are you aware that there is no medication on the market, that I know of, which claims to reverse the symptoms of Pd?

I took meds for eight years, but I stated to do fast walking after two years and also learned haow to consciously control my walkking movements to overcome the shuffle. I also became POSITIVE about my future prospect because I had started to get better after only four months of the fast walking. I have not needed to take any Pd meds since 2002,

If you try fast walking and it does not work for you then what have you lost?

[kevowpd in reply to JohnPepper]

Can you stop it with your relentless spam?

[Intrepid200]

Justin Am taking Rytary 48.75mg_195mg and I ts working steadily for me. I have tried all the versions of Rytary and so far my magic pills if your medical plans will cover it look into combine Gocovri with Rytary before you stio taking Rytary

[Intrepid200]

Follow up Justin are you aware that Rytary comes in four Dosage have you tried the lower dosage 95 mg ,or 145mg I n my case I was on the 146mg and it was not working steadily and I told my neurological te that I want to increased the strength and they move to 1 95Mg