Somebody on FB had a link to a Noni Juice Cures PD page (they were selling Noni Juice) so I figured I would look for some science behind it. I will probably add this to my diet.
Morinda citrifolia mitigates rotenone-induced striatal neuronal loss in male Sprague-Dawley rats by preventing mitochondrial pathway of intrinsic apoptosis 2017 pubmed.ncbi.nlm.nih.gov/278...
Morinda citrifolia and Its Active Principle Scopoletin Mitigate Protein Aggregation and Neuronal Apoptosis through Augmenting the DJ-1/Nrf2/ARE Signaling Pathway 2019 hindawi.com/journals/omcl/2...
Overall, from the in vivo studies, it is clear that MCE, with its antioxidant property, scavenges the free radicals, and it also reduces the expression of iNOS and prevents rotenone-induced aggregation of α-synuclein. MCE also augments the total levels of Nrf2 and subsequently translocates Nrf2 to the nucleus by preventing its degradation mediated by Keap1/Cullin3 complex which in turn leads to transcription and enhanced activities of its downstream effectors γGclc, Ho-1 and Nqo1. This neuroprotective effect of MCE might be attributed to the presence of identified phytoconstituents quercetin, rutin, and scopoletin and also other unidentified constituents [10]. However, as scopoletin is the biomarker for Morinda citrifolia [29] while other compounds such as rutin and quercetin are commonly present in most of the plants [30, 31], further emphasis was given to scopoletin, and its mechanism of action in boosting DJ-1/Nrf2/ARE pathway was studied in in vitro cell culture using SH-SY5Y dopaminergic cells, in order to delineate the ability of the phytochemical derived from Morinda citrifolia on dopaminergic neuronal cell survival.
Morinda citrifolia Linn. (Noni) fruit, antioxidant effects, and neuroprotection researchgate.net/publicatio...
The Nrf2 Project - Exhibit A
Short Chain Fatty Acids, sodium butyrate, phenylbutyrate
