Nrf2 activator rankings

[Bolt_Upright]

A 2024 cell study compared and contrasted findings of previous plant compound Nrf2 inducer studies with a newer assay type:

“Various plants have been reported to contain compounds that promote transcriptional activity of Nuclear factor erythroid 2-related factor 2 (Nrf2) to induce a set of xenobiotic detoxifying enzymes, such as NAD(P)H-quinone acceptor oxidoreductase 1 (NQO1), via the antioxidant response element (ARE). An ARE luciferase reporter assay was recently developed to specifically assess Nrf2 induction potency of compounds.

33 compounds were sorted in the order of their transcriptional activity of Nrf2. CD value is the concentration of a compound required to double the basal activities of individual enzymes or luciferase activity.

surfaceyourrealself.com/202...

[reedboat2]

Thanks, Dave. A good reminder to stay on the SFN train - JG

[Boscoejean]

I was kind of interested in the sources of some of these - make a list and find out what plants they come from. Some of them seem fairly obvious and some less so.

sulforaphane of course we know the sources- broccoli, brussels sprouts, cabbage, bok choy, and collard greens

I typed up this list because it can be cut and pasted if a person wants to print the list since you cannot cut and paste the chart in the study. Now that I have the list I can find out all the plant sources of each of them. Some are available as single supplements and I will underline the ones I have seen. Having the list the sources could be listed

sulforaphane

withaferin A

Andrographolide

Erucin

Tanshinone

Pterostilbene

Luteolin

Apigenin

Xanthohumol

Resveratrol

Galangin

Emodin

3H 1,2 dithiole-3-thione

Hesperetin

Genistein

Picetannol

Curcumin

Bacalein

Quercetin

Isorhamnetin

Benzyl-isothiocynate

Caffeic acid phenethyl ester

Kaempferol

Morin

Epigallocatechin

Rosmarin

Caffeic acid

Mangiferin

Myrecetin

Ginsenoside

Solvianolic acid

Ferrulic acid

Naringen

[dvoranel]

Thank you so much Dave. Inspiration to eat those broccoli sprouts every day, rain or shine!

[Zella23]

Thanks very much, great information.

[Isotope]

foods that activate Nrf2 according to ChatGPT include;

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that plays a key role in cellular defense against oxidative stress by regulating the expression of antioxidant and detoxification enzymes. While Nrf2 itself isn’t a food component, certain compounds in foods can activate Nrf2 pathways, enhancing its beneficial effects. These foods often contain phytochemicals such as sulforaphane, curcumin, or polyphenols.

Here are some foods known to activate Nrf2:

1. Cruciferous Vegetables (Rich in Sulforaphane)

Broccoli (especially broccoli sprouts)

Kale

Brussels sprouts

Cauliflower

Cabbage

2. Berries (Rich in Polyphenols)

Blueberries

Strawberries

Blackberries

Raspberries

3. Spices

Turmeric (contains curcumin)

Black pepper (enhances curcumin absorption)

Ginger

4. Green Tea

Contains epigallocatechin gallate (EGCG), a strong Nrf2 activator.

5. Citrus Fruits

Oranges

Lemons

Grapefruits (rich in flavonoids like hesperidin and naringenin).

6. Nuts and Seeds

Walnuts

Flaxseeds

Sunflower seeds

7. Dark Leafy Greens

Spinach

Swiss chard

Arugula

8. Allium Vegetables

Garlic

Onions

Leeks

9. Fermented Foods

Kimchi

Sauerkraut (may support overall antioxidant pathways).

10. Legumes and Pulses

Lentils

Chickpeas

Black beans

Additional Tips:

To maximize Nrf2 activation, focus on lightly steaming vegetables (like broccoli) to preserve sulforaphane. Also, pairing foods with complementary compounds—such as turmeric with black pepper—can enhance their bioavailability and effectiveness

[Emanuelfrb]

This reminds me of this study:

The current pharmacological treatment for Parkinson's disease (PD) is focused on symptom alleviation rather than disease prevention. In this study, we look at a new strategy to neuroprotection that focuses on nutrition, by a supplementation with Açai berry in an experimental models of PD. Daily orally supplementation with Açai berry dissolved in saline at the dose of 500 mg/kg considerably reduced motor and non-motor symptom and neuronal cell death of the dopaminergic tract induced by 4 injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Furthermore, Açai berry administration reduced α-synuclein aggregation in neurons, enhanced tyrosine hydroxylase and dopamine transporter activities, and avoided dopamine depletion. Moreover, Açai berry administration was able to reduce astrogliosis and microgliosis as well as neuronal death. Its beneficial effects could be due to its bioactive phytochemical components that are able to stimulate nuclear factor erythroid 2-related factor 2 (Nrf2) by counteracting the oxidative stress and neuroinflammation that are the basis of this neurodegenerative disease.

pubmed.ncbi.nlm.nih.gov/359...

[rebtar]

I'm wondering who the author of tbis blog is?

[Bolt_Upright in reply to rebtar]

He never identifies himself. He sure is dedicated to whatever it is he is doing.