In case you missed it, Part 1 of this post where I laid the foundation for the idea and reason for my current regimen is here :
When I wrote that post 3 weeks ago, I had already started a self experiment to try and test whether this theory had any merit. If this theory is correct it should have benefit for a multitude of diseases not just PD, similarly to Fecal Microbiota Transplantation( FMT ) with positive health effects in many diseases. I had decided that I would test this theory for 12 weeks to try and replicate the length of the 2021 FMT Study.
As some of you may be aware, I have severe psoriasis in multiple forms, two of which almost killed me and landed me in the hospital with about 95% body coverage. I have battled with psoriasis for decades and though in recent years I have been able to manage it fairly well using an assortment of natural products that have produced mixed results of varying degrees. Despite my many efforts my previous best response was as high as 95% clear skin, but that turned out to be short lived and I have since been bouncing around between 70% clear to 90% clear, but I have never made it back to 95% clear again and it seems that each attempt to recover from a disease exacerbation was met with greater resistance and length of time to recovery in an age dependent manner. To say that a little differently, the older I get, the harder it is to recover from any disease exacerbation and the longer it takes me to start to see any benefit. I was about 80% clear when I started this regimen.
I have been testing my current regimen for about a month now in an attempt to see if I could potentially replicate FMT effects as observed in the study over the 12 week study period without actually using FMT. Now you may say that psoriasis is not PD and you are exactly right, but the benefit in the study was seen in PwP not people with psoriasis. The interesting thing with FMT is that it appears to benefit many different health issues and psoriasis is supposed to be one of those issues, so if it works for PD, there is a good chance it will work for psoriasis, even severe psoriasis.
At about 5 weeks in to using this regimen, I would like to discuss my results so far. At about a bit over one week in, I had the impression that my current exacerbation was no longer worsening. At about 2 weeks in, it seemed like I might be seeing actual improvement. At about three weeks in, improvement seemed to be continuing at a rate where I could actually see small visual improvements day to day or every other day.
I am now about 5 weeks into this regimen and what I see is that I am still seeing daily to every other day small improvements in my skin coverage area, but very importantly, it appears that I am now at least 95% clear again and so far the trend is continuing! I am very happy and excited with these results! Also important and worth mentioning is that during this time I have also been dealing with a very stressful personal situation in my life that would have surely exacerbated my psoriasis quickly and relentlessly, but that has not been the case this time.
One interesting point about psoriasis and the only interesting one that I am aware of, is that because its effects appear on the surface of the skin, it makes me a guinea pig of sorts as I can fairly quickly see how the skin reacts to changes in my supplement regimen and this is what allowed me to see how quickly this regimen is working in me! Well at least I found one good use for this horrible disease! What is that well known saying, "when life gives you lemons, make lemonade"?
So what regimen am I doing to achieve these results which to me are very impressive? It is very simple and I have mentioned them on the forum at various times. Some of you on the forum are aware that I am taking 106 + mg of melatonin every night and I believe that has kept me from a severe exacerbation as I have had many times before, but not since the addition of 106 mg+ of melatonin now in the beginning of my 11th month at this dose.
One major finding about FMT is that it increases gut melatonin levels so this is something I want to include with this regimen. Melatonin production declines with age and even more so with PD, so this seems like an important step in trying to replicate FMT, but I think melatonin supplementing is only needed temporarily in this process until higher gut melatonin production is restored through increased SCFA levels and it may potentially speed the process up. According to Dr. Mailing in her video in part one, it is very important to activate PPAR-y and melatonin does this at the gene level! She says activating PPAR-y is like throwing a switch that promotes repair of the gut microbiota to get rid of gut dysbiosis
What I added was high dose thiamine microlingual at 400 ~ 600 mg/day. The reason for this is that thiamine is produced in the gut. PD is known to have gut dysbiosis and psoriasis is too. Gut dysbiosis is known to disturb this natural production of thiamine and I wanted to be sure I have plenty of thiamine to cover what I may be losing from gut dysbiosis.
In a recent post, I discussed how one of the important effects of thiamine in the body was helping to control the production of the inflammatory cytokine IL-17. In healthy controls IL-17 is generally undetectable, but in PD and psoriasis, IL-17 is activated and promoting the inflammatory cascade. I discussed this here:
Keep in mind that FMT appears to restore normal gut health and one of those things that are restored would be natural production of thiamine in the gut, so I felt it was an important aspect of how FMT is working as well as it does and since I am trying to replicate some of the major features of FMT, thiamine had to be included.
The next item of this regimen is pistachios in three servings per day which is my snack food in place of any junk snacks. Why pistachios you may ask? A few reasons actually. Pistachios are reported to increase bacteria in the gut that can create Short Chain Fatty Acids (SCFAs) when they are delivered with prebiotics or fermentable fiber. Pistachios also happen to contain fiber! Pistachios taste good (to me) and are very healthful. Pistachios also have one of the highest contents of melatonin in any type of food. I use a container such as the size they give you salad dressing or ketchup in at a restaurant. My container holds exactly 4 ounces of water when filled to the brim. I use this container to scoop pistachios out of my big bag and fill the container to overflowing with pistachios and I eat three of these spread out through the day.
In "part one" of this post, I discussed a potential synergy between melatonin and Short Chain Fatty Acids (SCFAs) where they feed off of each other to promote production of more SCFAs, melatonin and melatonin receptors, which I theorize all work together to promote healthful bacteria, repair of the gut mucosal barrier, protection of the epithelial cells, reversal of gut inflammation, decrease gut oxidative stress, repair gut dysbiosis, shift the gut microbiota toward health promoting bacteria and away from pathogenic bacteria to ultimately reduce disease symptoms significantly. Together they do much more, but these are the basics of what I describe as a "pro-health repetitive cycle".
The other thing I am doing is walking 2 miles a day at a brisk pace. Exercise has shown in studies to increase gut content of SCFAs and we need those SCFAs to stimulate this process.
One thing I have not introduced that I had planned to was fasting because this too increases SCFA promoting bacteria or SCFAs, but I will keep this option on the back burner in case I need extra help as I have had good results with intermittent fasting in the past and I trimmed down with it and just seemed to feel better. For now, I have not needed to add it as the basic regimen is working very well.
So although I have psoriasis and not PD, I seem to be responding similarly to how those PwP did with FMT and I hope that this regimen can work similarly in PD as it is with my psoriasis. Twelve weeks is about 7 weeks away for me at this time.
Well that is my complicated regimen that I wanted to share with all of you and my intent is to eventually reduce or stop my melatonin supplementation and count more on the gut produced melatonin, but the condition of my skin going forward will probably help determine what I do and when. On a related note, it is possible that I continue high dose melatonin due to Covid-19 as FMT has also shown benefit in Covid-19, but right now, I just want to enjoy my current very improved skin condition! It is wonderful!!!