William (Bill) Curnow - Biomic Life

[Bolt_Upright]

I stumbled across this while looking for examples of patients of Dr Borody (the godfather of FMT). Bill Curnow is a retired Australian Architect & Professor who has Parkinson's and had impressive improvements from antibiotics. He also later had FMT but said that did not make a difference.

Anyway, Bill has a web site where he shares his story and his theories on PD and it is fascinating. It is a single page and you just start at the top and scroll down to read everything. It is arty also: biomiclife.com/

[Bolt_Upright]

This is an interesting part:

"Methods/Clinical Incident: In 2011 I was hospitalised for bowel obstruction and after antibiotic infusions I noted surprisingly that my PD symptoms virtually disappeared. My notes/drawings before and after treatment graphically illustrated the difference. Silburn (my Neurologist) was surprised when I explained - “Cessation of PD symptoms was like turning off a switch”.

Outcome: After discharge PD absence lasted only 2 weeks. If antibiotics suppressed gut bacteria I postulated their toxins caused PD in the brain and connecting nerves must also be implicated. Via literature I located Borody (Gastroenterologist) who administered IV metronidazole + ceftriaxone and PD again disappeared. Effect tapered somewhat after two weeks. This was followed by oral metronidazole and cefaclor which maintained improvement over months but at a reduced efficacy. In 2014 I noted improved motor function immediately after defecation, perhaps due to reduced gut bacterial load and toxins interacting indirectly with gut neuronal axis according to Aylward [CSIRO scientist]. Measured physical performance before and after treatment confirm empirical observations."

Okay, this part is my thoughts:

Okay, close your eyes when you read this, but have you ever had a headache and it go away when you defecate? Is this an example of the gut brain connection?

Bolt

[Bolt_Upright]

This got me thinking about antibiotic treatments for PD. Found this interesting article on CMT-3. Seems to work. Seems to have a good chance of causing Lupus

CMT-3: A better option than doxy? November 22, 2020

scienceofparkinsons.com/202...

[M-o-ggy]

I was given anti biotics for something else and my symptoms improved for a while.

[Bolt_Upright in reply to M-o-ggy]

What were you taking M-o-ggy?

[park_bear]

Antibiotics taken for other purposes have made no difference to my symptoms.

[M-o-ggy]

I don't remember. What it was. I think it was for a tooth infection. I can remember mentioning it to my Dr who basically ignored my comment.

[M-o-ggy]

Hi there. I don’t know. It would not have been penicillin as I react to that.