Does dissolving C/L under the tongue give faster ON?

[Rebtar]

I saw these case reports:

medicinenet.com/carbidopa_w...

And it made me wonder, does dissolving C/L under the tongue get it into the bloodstream? From the case reports it seems so...

So why isn't it used more?

I just did a personal test -- since I ate later than planned and food interferes with my C/L absorption, I dissolved the tablets under my tongue, let them sit for a bit and then swallowed with a whole glass of water (there didn't seem to be much left).

Anyone experimented with this?

[Astra7]

Yes. I chew them and push the mush against my gums. The chewing speeds it up but the mouth absorption doesn’t seem to do much.

[Hidden]

Hi rebtar, No, it doesn't get into the blood stream under your tongue. I guess the document you provided the link to refers to the "orally disintegrating tablets" which are made for people who are unable to swallow tablets...

To get a fast reaction, I chew a regular IR tablet tablet and wash it down with water.

I think the fastest reaction may be had by crushing a tablet with a mortar and pestle and stir into a glass of water (and then drink it)(AKA "liquid sinemet")...

Whatever way you do it, it still gets absorbed in the small intestine.

[laglag]

I've always used ODT - Orally Disintegrating Tablets. Started C/L around 12 (+/-) yrs ago and I prefer them. They used to be called Parcopa but now they refer to them as C/L ODT. My dosage back then was 4 Odt's per day, now I take 5 regular C/L's and 3-5 1/2 Odt's. I use them now to get me through to my next regular time, if needed. As far as your question, the Odt's kick in within 15 - 30 minutes in comparison to about 45 - 60 minutes for the regular.Levod made said the Odt's go through the intestines like the regular. I have always been curious about that but never asked my doctor. I would ask your doctor about the Odt's.

Keep fighting! 🥊

[GymBag]

I use regular blue LD/CD tablets , chew them and follow with a hot coffee. Seems to get the fastest reaction. They dont taste that bad.

[Buckholt]

As far as I know, Levodopa is absorbed in the duodenum, so needs to be swallowed and leaving in the mouth won’t achieve anything

[PDGal4]

I also chew half a tablet between Rytary doses. No real offending taste. I'll drink a little water afterward. Takes about 20 minutes to kick in.

[Zardoz]

I dissolve a tab under the tongue first thing upon waking, and then rinse it down with coffee. It usually kicks in in about an hour.