Chicory extracts increase neuronal survival in Parkinson’s

[Gigi216]

patents.google.com/patent/W...

[JayPwP]

Good info

[Gigi216 in reply to JayPwP]

Yes it is a bit long lol but I think it sounds very promising! I definitely purchased some to use in my coffee each morning! Glad you enjoyed it

[faridaro in reply to Gigi216]

I also enjoy having roasted chicory "coffee" in the morning with mannitol, coconut milk and cinnamon. Makes it even better knowing the chicory's benefits.

[Gigi216 in reply to faridaro]

Yes I buy chicory coffee at the store. I was amazed at the benefits when I read the research. I’m so glad I happened to find it and I’m glad to share! The way you do it with the mannitol, coconut milk and cinnamon sounds so delicious I’ll have to try that myself 😁

[faridaro in reply to Gigi216]

I buy roasted chicory root granules by Frontier Co-op (1lb) at Vitacost website. They also have mixtures of chicory root with some grains as coffee substitutes.

[Missy0202 in reply to Gigi216]

Can you tell me a bit about how you use and purchase the chicory? I will follow your lead as usual

[bassofspades]

French Market Coffe!!

[jenniferdunstan]

Could you please share the way to make the chickenric coffee concoction that benefits neuronnal health.

[Gigi216 in reply to jenniferdunstan]

Down below you notice faridaro says she uses mannitol, coconut milk and cinnamon. I would think that would be very beneficial for neuronal health

[Rhyothemis]

Might not work orally

pubmed.ncbi.nlm.nih.gov/280...

pubmed.ncbi.nlm.nih.gov/332...

OTOH, dandelion tea has been used for cancer and the anticancer effect is though to be due to sesquiterpene lactones - so I'm not sure why dandelion lactones are orally bioavailable but chicory's are not.

The inulin in chicory is supposed to be good for the gut microbiome.

[Gigi216 in reply to Rhyothemis]

Well I found this study about using inulin as a drug delivery system because it increases bioavailability so that would be unusual if chicory didn’t work because it is loaded with inulin

tandfonline.com/doi/pdf/10....

[Gigi216 in reply to Rhyothemis]

I’ll have to keep researching that! I see that study says that

[Gigi216 in reply to Rhyothemis]

Also if the studies that were done saw benefits in neurodegeneration I think that should be able to be replicated because if not orally bioavailable how did they get benefits when chicory was given?

[Rhyothemis in reply to Gigi216]

That's a good find on the inulin. The roots have it, not so much the leaves. The methods in the Weng 2020 paper don't even specify if they used the root or leaves, but people typically juice the leaves, so I will assume the latter.

The patent and the Venkatesan 2017 paper both used in vitro (cell culture) studies.

[Gigi216 in reply to Rhyothemis]

The study I posted specifically says roasted chicory root so they are using the roasted root for the study on neurodegeneration

[Gigi216 in reply to Rhyothemis]

Does that mean you feel cell culture studies aren’t accurate? Don’t most studies use these? If most studies use cell cultures are you saying they aren’t any good? I’d definitely like to understand that better I don’t have expertise in cell culture studies

[Rhyothemis in reply to Gigi216]

You can't tell from a cell culture study of a drug whether when taking it orally it will get where it needs to go. The drug has to get into the blood stream and if the site of action is the brain, then it also has to cross the blood brain barrier. In this case, the inulin may help, but after skimming the paper on inulin improving bioavailability, it does not address whether the inulin can stop lactucopicrin from being broken down (metabolized by phase II glucuronidation).

Cell culture studies have their place and can be informative - but like all model systems they have their limitations. There are other issues besides bioavailability, but that's the first hurdle.

I don't think adding chicory to the diet will be harmful and it may have benefits - and if you enjoy it, then all the better.

[Gigi216 in reply to Rhyothemis]

Thank you for explaining that to me I appreciate that. I do enjoy it and will continue to consume it! I found a study saying it was verified to cross the blood brain barrier! It just sounds like a wonder nutrient

faseb.onlinelibrary.wiley.c...