I ask the group help with this question: B1 oral vs injections

“My hwp general doctor agrees that B1 necessary. Questioned how do injections work twice a week if B1 doesn’t stay in your body ? We couldn’t answer him. Anybody know science of it? Thank you !”

[kaypeeoh]

Just a guess; it's water-soluble so it gets used and excreted in urine. But never builds up. Blood tests say my B1 is 7 (8-30) so I take 100mg of B1 sublingual daily.

[Despe in reply to kaypeeoh]

hdri-usa.com/

This is a lab in NJ where they check your true B1 values.

[Gioc]

"Discussione

Il meccanismo di assorbimento della tiamina è stato alquanto controverso. Un gruppo di ricercatori ha concluso che la tiamina viene assorbita solo da un meccanismo di trasporto attivo saturabile nell'intestino tenue prossimale; tuttavia altri ricercatori hanno dimostrato che anche la tiamina viene assorbita da un processo passivo [13]”.

ncbi.nlm.nih.gov/pmc/articl...

//

//

//

A comparison between Intramuscular and pills:

"Ten healthy men were given 500 mg thiamine i.m. once a day (Group 1) and ten were given 250 mg p.o. every 12 h (Group 2). The times to reach steady state (7 and 5.6 days for Groups 1 and 2, respectively) were not different (P>0.05). The mean elimination half-life was 1.8 days. The mean minimum steady-state concentration after the oral regimen (23 μg·l−1) was 78% of that after the intramuscular regime (29 μg·l−1).

link.springer.com/article/1...

[nellie58]

Once you are well established on B1, it takes several months for the benefits to disappear if you stop. So this must mean that there is a residual effect? The injection form is more immediate but both work.

[ion_ion in reply to nellie58]

I stopped it for 3 months in order to see some symptoms coming back.

[Dap1948]

I take 100mg of sublingual B1 every OTHER day but notice no difference in my symptoms the day I don’t take it. I presumed that the benefits B1 stimulates, like making that enzyme work (that I’ve read about but don’t fully understand), that that continues without daily stimulation.

[Husbandsupporter]

I would suggest you contact the Michael J Fox Foundation, the Davis Phinney Fondation, and the National Parkinson's Fondation and ask about research on benefit or not, of B1. I've heard and read mixed theories.

Are you taking other supplements?

[Hidden in reply to Husbandsupporter]

“0” supplements

[parkie13]

Hi Roy, the only thing I would make sure is that the injectable thiamine HCL does not have aluminum in it. When I started I decided against injectable since I could not find any that does not contain aluminum. I had hair analysis done in the beginning and I had a very high score of aluminum. Mary