🧠 Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

[Kia17]

Markers of neurodegeneration (APP, alpha-synuclein) are related to markers of methylation (SAM, SAH) in patients with PD. Better cognitive function was related to higher methylation potential (SAM/SAH ratio).

pubmed.ncbi.nlm.nih.gov/196...

The ratio of SAM:SAH is frequently used as an indicator of cellular methylation capacity, whereby a decrease in this ratio predicts reduced cellular methylation potential. Folate is integrally involved in both substrate synthesis and product removal via its role in methionine synthesis from Hcy.

🧠 Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

jneurosci.org/content/30/18...

[MarionP]

Is there some point of discussion here?

[Hardisk70 in reply to MarionP]

I guess just to learn about it and be on alert for new clinical trials revolving around it....

[Kia17 in reply to MarionP]

It’s about the importance of methylation and keeping it in balance.

[MarionP in reply to Kia17]

And how does one do that?

[Kia17 in reply to MarionP]

There are many ways to do that.

First of all to check our genetics tendencies via a simple test for some popular genes like MTHFR, and then try to help weak spots after they are identified via supplementation or lifestyle changes, in another word with epigenetics interventions.

[alexask in reply to MarionP]

Drink wine?

[Kia17 in reply to alexask]

I don’t think drinking wine would help methylation .

[MarionP]

I don't still see something specific enough to implement or measure application and outcomes. All seems rather vague yet.

[Kia17 in reply to MarionP]

Why do you think so?

There are whole bunch of science backing importance of methylation.

[MarionP in reply to Kia17]

I should think that "why" is self obvious, I don't see any actual action steps to answer what I just asked. If you can't point to such things, I don't also see if you know what you are talking about.

Your equivalent of "Everybody knows that" is not sufficient. Are you trying to help or what, the trail seems to end very abruptly.

How many look at these answers and go "right, what? I have to go design and build my own car, you say they exist and I should just build one. Hardly credible. Honestly. You don't see that?

[Kia17]

You are right. I don’t know what I am talking about. 👏 👏

[MarionP in reply to Kia17]

Since you put so much effort into resistance instead of clarification, yes I'd have to agree. If you could explain or if there was sand to what you say, then you likely would do so. Instead you bounce it. At very least you would say (and actually want to say), "Here's how I do it, and here's how I know it works." The thing speaks for itself.

[Kia17 in reply to MarionP]

👍👍

[MarionP in reply to Kia17]

As Rumi once said.

[Hidden in reply to Kia17]

Kia17, thank you for sharing this information. Sincerely. I will use it as a spring board to research more.

[rescuema in reply to Hidden]

cc, this is the reason why I recommended to you the GDX methylation panel test a while back. It specifically measures for this and detects any genetic polymorphism that contributes to the methylation issues along with possible nutrient deficiencies. gdx.net/core/sample-reports...

[Hidden in reply to rescuema]

Thank you Rescuema. I forgot about it. So much to learn. I will seek it out.

[Kia17 in reply to Hidden]

You’re welcome. It's really worth it.

[Kia17]

Exactly 😊

[Gigi216]

Yes great information on importance of supporting methylation pathways for positive genetic expression!

[Oceanwind]

Thank you for posting this Kia. I really appreciate your posts.

[Kia17 in reply to Oceanwind]

You’re welcome

[Kia17]

Please see this video if interested in methylation subject.

youtube.com/watch?v=RSN_uRi...(Not working as expected?)