video: Low-dose ketamine produces long-te... - Cure Parkinson's

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video: Low-dose ketamine produces long-term reduction in levodopa-induced dyskinesia

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youtu.be/4sygods1Txk

Preclinical data has previously suggested that low-dose ketamine treatment has short-term antiparkinsonian activity and can reduce levodopa-induced dyskinesia in the long term after an initial 10-hour total treatment. Torsten Falk, PhD, University of Arizona, Tuscon, AZ, discusses the rationale and results of the open-label, dose-finding Phase I/II clinical trial testing the safety and tolerability of low-dose ketamine infusion to treat levodopa-induced dyskinesia. To mimic the 10-hour infusion used in the preclinical model but to be suitable for outpatient use, two 5-hour low-dose ketamine infusions were given within one week. The study results look promising, with over 50% reduction of dyskinesia from baseline during infusion two and 41% reduction at three months post-treatment. The effects on parkinsonian symptoms, captured with UPDRS, were also measured: 27% reduction during infusion two. A multicenter, double-blind, placebo-controlled Phase II/III trial (NCT04912115), with midazolam as an active-placebo, is planned to start before the end of the year. This interview took place at the 2022 International Congress of Parkinson’s Disease and Movement Disorders in Madrid, Spain.

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park_bear profile image
park_bear

Trial listing:

clinicaltrials.gov/ct2/show...

corporate sponsor:

pharmather.com/

Canddy profile image
Canddy

I participated in the open-label, dose-finding Phase I/II clinical trial and the ketamine worked for me. I plan on participating in the Phase II/III trial if I am eligible based on the inclusion/exclusion criteria.

SAGoodman profile image
SAGoodman

Does anyone have knowledge or experience with low-dose ketamine treatment used for non-levodopa-induced dyskinesia? I am still drug-free through supplementation, but still battle slow movements sometimes.

Juliegrace profile image
Juliegrace in reply toSAGoodman

”Non-levodopa induced dyskinesia” is there such a thing? Are you confusing bradykinesia with dyskinesia?

SAGoodman profile image
SAGoodman

i was referring to my right side slowness of motor skills, not tremor. I was incorrect with the proper word. Thank you for correcting me

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