A new study adds further way of understanding PD occurrence biologically " In a mouse study, scientists have shown that distinct neural pathways in the brain are associated with motor function issues and cognitive decline. They conducted a study in mice to understand the relationship between neural circuits in the brain and some of the functions that are typically affected by Parkinson’s disease, such as cognitive and motor abilities.
They looked in particular at the external globus pallidus (GPe) in the brains of mice, which previous research has linked to the motor symptoms of Parkinson’s.
The researchers used multiple methods to give a more detailed overview of this region of the mice’s brains, including electrophysiology, viral tracing, and behavioral experiments. The researchers identified two areas of the GPe and were able to relate these areas to motor skills and cognitive skills in the mice.
By manipulating neurons in these two parts of the brain, the scientists improved the mice’s locomotion and their reversal learning. " Study Excerpt .
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