Research

[Ghmac]

Ran across this study ...thought it might be of interest... mentions PWP

theguardian.com/society/202...

[LAJ12345]

Gosh very vampiresque!

[JohnPepper]

The world is already overloaded with old people, who have far exceeded the three score years and ten. If they were to start work again the only thing that will change is the quantity of unemployed would go up and the quantity of pensioners would come down, Neither of these two groups do we need! I am 86 and should have gone to the happy hunting grounds long ago.

[MUCU in reply to JohnPepper]

They Pharmancy bosses don’t want a cure us patients with Parkisons they make millions with this terrible medicine that only helps a little a destroy our lives that my view . Only money matters nowadays sadly 😥

[JohnPepper in reply to MUCU]

It has generally been the motive for most business decisions. We have to live with that, but be strong enough to fight it and get people to realize they have been misled. But be careful, the only misleading could have happened if they already knew that fast walking can reverse Pd symptoms.

[Baron1]

This has further advanced from what my research has shown, since 2020.

It is clearly an avenue for further development.

This type of procedure is extremely beneficial when taking into account that certain proteins diminish as we age.

Like the protein called GDF11, GPLD1, TIMP2, and Klotho produced in the kidneys.

They react with other proteins in the body to produce remarkable results in reversing the aging of the brain, kidneys, liver, and heart.

There is more, but I would be writing a thesis just here if i continue.

Great topic to read about.

[Rhyothemis in reply to Baron1]

Conboy et al have reported the benefits derive more from dilution of pro-aging factors in the old blood - mainly TGF beta family proteins.

rhyobrain.blogspot.com/2020...

[Baron1 in reply to Rhyothemis]

Thank you for your input.

However, the research you have suggested is not the same as what I have described in my post.

Your research is interesting but has flaws in its research, and your belief that the answer lies in old blood factors.

There has been, and there is more research into young blood proteins clearly showing the necessary interaction creating the change in how aged cells and the cells in general perform.

The research you are relying on is similar to the saying; "One swallow doesn't make a summer".

Further research would have to be done to support this theory and whether it is more potent than using the blood of younger people, who have the necessary proteins I spoke about, that are critical in interacting with the bodies cells in a positive manner.

So keep up the discussion, as all input allows us to all to discuss what can and what might be possible in the near future.

[Rhyothemis in reply to Baron1]

The Conboys originated research into heterochronic parabiosis for aging; initially they proposed factors such as GDF11 as being responsible for the anti-aging effects, but have revised their views in light of further experimentation - and I don't see any flaws in their research except perhaps for need to better control for the effects of supplying albumin and also dilution increasing EPO (but as I noted in my blog post EPO can help, but not that much).

I know some in the field disagree about the relative benefits of taking away pro-aging factors vs. supplying anti-aging factors, e.g, Wyss-Coray (I posted on this forum on his talk recently) but note that Wyss-Coray started a company, Alkahest, that provides young blood factors as a treatment- so perhaps he is a bit biased.

The albumin question is a bit tricky, but we know that elderly people

with higher albumin levels - their own, old albumin - have lower

mortality (and higher albumin levels are associated with better covid

outcomes in hospitalized patients). I think Wyss-Coray has implied that young albumin has rejuvenating effects - and perhaps it does - but the albumin

doesn't contain GDF11, etc.

Btw, Michael Lustgarten has found that increasing his dietary carotenoid intake increases his albumin levels. That's just an n=1 experiment, but it is easy enough for people to replicate it; albumin is on the blood chemistry / CBC panel sold by LifeExtention, regular price is $35, on sale now for $26

[Rhyothemis in reply to Rhyothemis]

The factors in question may not be all proteins but could include circulating miRNAs and I haven't seen this addressed, maybe it has been and I just missed it; circulating miRNAs have been investigated as aging biomarkers & also in context of cell-free stem cell exosome therapies.

[kaypeeoh]

Not exactly the same thing but close; I remember a study from 20 years ago. Regular blood donators had much less incidence of cardiac disease. The theory is by removing blood the bone marrow ramps up production of new, young red blood cells. At the microscopic level older red cells become stiff and can't bend around tight capillary junctions. Instead they stop flowing and if enough collect then a clot will form. Young cells bend easily through these junctions.

Similarly, ozone injections keep red cells young by keeping them supple so they're less likely to form clots.

[Rhyothemis in reply to kaypeeoh]

I don't think that's been completely validated as there is the confounding 'healthy donor' effect - that is, healthy people self-select for blood donation. Some men do regular blood donation as part of their health regimen and I don't see a problem with it - it might help. They could track their biomarkers and see if they notice a difference.

[Rhyothemis]

Video on experiment where rats were injected with young plasma; the vlogger scaled the dose for humans and the dosing is actually quite reasonable. The results were remarkable and I hope they can be replicated. Copy/paste of my YT comment on mechanism re: pro vs. anti-aging factors:This is a matter of some debate. The Conboys' dilution experiment had me convinced that mostly the benefit is from dilution of TGF beta family proteins (pro-aging factors). I thought Wyss-Coray was perhaps a bit biased due to his involvement with Alkahest. But this experiment, and also research that suggests benefits to albumin*, has me wondering. (*studies showing higher albumin levels associated with lower mortality and better health outcomes; maybe it is just a marker of better liver function, or perhaps more albumin really is better when aged if it makes up for a loss of function.) Maybe both camps are right, maybe young (or higher amounts of) albumin does something to mitigate harmful effects of pro-aging factors. I should note that albumin is not really one entity, but a mix of proteins that also carries other substances.

youtu.be/zhUSymeSOnM(Not working as expected?)

[Hidden]

Fascinating and an uplifting prospect. Plasma therapy is being added to my mental list of therapies that will one day potentially help me and other PWP.

Thank you for adding to my reasons for hope.