Further Roche vaccine trial data

[Parkinsonjisung]

Some interesting data here. Main one probably being that not targeting specific patients types in a trial is a waste of time

alzforum.org/news/conferenc...

[WinnieThePoo]

It was interesting at my final spark visit on Friday, that the research coordinator was saying she wouldn't be surprised if there was a reanalysis of the data and more positive results announced.

[Parkinsonjisung in reply to WinnieThePoo]

The data is a bit muddled. Feels like they're cherry picking the good data to convince themselves it works. Saying that there's probably enough interesting data to tweak and try again. Let's hope the 2nd trial has more robust data.

[kevowpd in reply to WinnieThePoo]

Didnt they take a $75m write down? Reckon you'd be pretty settled on a conclusion before doing that. On the other hand, maybe they had to, given the state of play at year end.

[Parkinsonjisung in reply to kevowpd]

Ya, you would of thought that would of been the end but evidently, they're doing a new trial

[kevowpd in reply to Parkinsonjisung]

Oh I thought WTP was referring to cinpanemab.

[park_bear]

It is only a waste of time when your intervention is not highly effective to begin with. A slight slowing of progression for an expensive IV treatment is not that exciting. That is is probably all you are going to get for an antibody that prevents growth of existing alpha synuclein complexes. What is really needed is something that breaks those complexes down, like this:

" Upon oral administration, xxxxxxxx markedly reduced the level of insoluble α-syn in nigra, hippocampus and brain stem"

[Parkinsonjisung in reply to park_bear]

The best analogy I heard from scientists that don't believe in this theory is: "its like trying to put out the fire by removing the ashes"

[park_bear in reply to Parkinsonjisung]

In this case the "fire" is a process that has taken many years to create a toxic waste dump that is now big enough to be in the way.

[Parkinsonjisung in reply to park_bear]

In the analogy, the fire is something else that cause dopamine cells to die and the ashes are the tangled alpha syncleuin and lewy bodies. I don't know which theory is correct but I'm beginning to lean towards the analogy theory.

[Canddy in reply to park_bear]

interesting article regarding antibody therapy apparently they cause a "fire"....

parkinsonsnewstoday.com/202...

[Parkinsonjisung in reply to Canddy]

Interesting

[park_bear in reply to Canddy]

Makes sense this would provoke inflammation, which is to say additional immune response. When an antibody attaches to something, that is the immune system's way of tagging it as dangerous.

[jeffreyn in reply to Canddy]

The corresponding research paper is now available on the PNAS website ($10).

Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia

pnas.org/content/118/15/e20...

[ryzlot]

As too-usual - the placebo out-performs the actual meds. I take 4 a day for perfect health, no side effects, no interactions.

JR