Fuzzy thinking

[Dholplayer]

I am on Madopar and I feel my thinking, reasoning seems to be dulled and slow... Anybody having similar experience?

[condor39]

I am on a high dose of Madopar with no side effects . I don;t think it is your meds

[Dholplayer in reply to condor39]

Thank you

[rescuema in reply to Dholplayer]

What are your b6 and b12 status? If you're not sure, I'd supplement and rule them out along with other possible nutritional deficiencies.

[Dholplayer in reply to rescuema]

I take multi vitamins and mineral with additional B vitamins complex

[rescuema in reply to Dholplayer]

That doesn't always rule out the potential deficiencies in people who have oral absorption issues, so if I"d try a sublingual methyl b12 at least since it most likely won't hurt, and try a methyl B complex instead if not already. Trying a HD B1 is also not a bad idea.

How is your blood pressure? Are you on any antihypertensive meds/supplements? I'd lookout for any sign of low blood pressure especially when you feel brain fog, and also a good idea to check with your DR and run a CBC to rule out any imbalance if the symptom persists. Also, try incorporating exercise such as a long walk and see if that helps.

[Dholplayer in reply to rescuema]

Much appreciated will try that... I tend to have high blood pressure but not so that I need to be on medication

[rescuema in reply to Dholplayer]

The meds can certainly affect the BP (high or low) so you should definitely monitor it closely in light of the fact on how you feel. More often than not, it's not all in your head.

"Care should be taken when using Madopar in endocrine, renal, pulmonary or cardiovascular disease, particularly where there is a history of myocardial infarction or arrhythmia; psychiatric disturbances (e.g. depression); hepatic disorder; peptic ulcer; osteomalacia; where sympathomimetic drugs may be required (e.g. bronchial asthma), due to possible potentiation of the cardiovascular effects of levodopa; where antihypertensive drugs are being used, due to possible increased hypotensive action.

Care should be exercised when Madopar is administered to patients with pre-existing coronary artery disorders, cardiac arrhythmias or cardiac failure (see also section 4.3). Cardiac function should be monitored with particular care in such patients during the period of treatment initiation and regularly thereafter throughout treatment.

Close monitoring of patients with risk factors for (e.g. elderly patients, concomitant antihypertensives or other medication with orthostatic potential) or a history of orthostatic hypotension is recommended especially at the beginning of treatment or at dose increases.

If Madopar is to be administered to patients receiving irreversible non-selective MAO inhibitors, an interval of at least 2 weeks should be allowed between cessation of the MAO inhibitor and the start of Madopar therapy. Otherwise unwanted effects such as hypertensive crises are likely to occur."

medicines.org.uk/emc/produc...

[Dholplayer in reply to rescuema]

😥😥

[mgregor6]

Me? I am on Stalevo, B1 2 grams 2X per day, Mucuna Pruriens (Zandopa 1.5 Tblsp 3X per day and

Nutrivita, 98% - 100% pure L-Dopa, Mannitol 1 Tblsp per day . Dulled and slow, yes! Was diagnosed January 2018.

But other factors are the main contributors, I Think.

I also take Trazadone 50mg (negative impact re: cognitive issues are one side effect ) side issues. For example, most nights I'm in bed at 10:30; awake 2 hours later at 12:30. Then, I toss & turn the rest of the night and get out of bed at 5:30am. It's that early because I cannot stand the symptoms any longer and the only thing that helps at this point are my morning meds, because the last ones were taken around dinner time. Dulled & slow? I can get like a zombie.....

[Dholplayer in reply to mgregor6]

Thanks for the reply

[gwendolinej in reply to mgregor6]

Hi there, have you tried melatonin at bed time. Works well for some.

[gwendolinej]

If you haven't had your bloods done, it's a good start, in case, as others have said, you are lacking something. My husband was very dull early on. The neurologist tried the Neupro patch. The result was amazing. It stopped working recently, so we tried mannitol, which did the same. (See my post).

It's all so complicated and varies so much from person to person, but you are certainly going to get support from members here. They are wonderful and really care.

Good luck,

Gwendoline

[Dholplayer in reply to gwendolinej]

Thank you for your reply