Motegrity helped me with the off time

[felixned]

I got prescription for Motegrity (2 mg) to help me with the constipation. It is effective and it positively changed how my Parkinson medication works. I could reduce my dose which helped with dyskenisia. It also greatly improved the off time frequency and severely.

[park_bear]

From the FDA label:

shirecontent.com/PI/PDFs/MO...

" 12.1Mechanism of Action

Prucalopride [Motegrity] , a selective serotonin type 4 (5-HT4) receptor agonist... In isolated GI tissues from various animal species, prucalopride facilitated acetylcholine release..."

sciencedirect.com/topics/ne...

Serotonin heading:

" 5-HT4 receptor–binding sites are localized with high density in the striatum, substantia nigra, and olfactory tubercle and have been reported in the hippocampus as well .... The 5-HT4 receptor is located postsynaptically to serotonergic neurons and modulates the release of several neurotransmitters (i.e., acetylcholine, dopamine and GABA)," [Emphases added]

You just found a new Parkinson's treatment.

[felixned in reply to park_bear]

Park_bear, thank you for this interesting information. For roughly 2 weeks after I started on this medication I didn't experienced any significant OFF periods. My sensitivity to animal protein seemed to be reduced. I thought that I could cut down on my Parkinson medication and sure enough for the past 3 weeks now for my two mid-day treatments I take only 1 Rytary pill instead of 2. This significantly helped with the dyskenisia. I noticed however that now I frequently remember my dreams (nightmares) which happened in the past very seldom. I wish I had 100 mg Rytary in addition to 200 mg I am currently on so that I could fine tune C/L intake.

[park_bear in reply to felixned]

Will your M.D. prescribe it if you request it? S/he would probably be interested to know about how the Motegrity is helping.

[felixned in reply to park_bear]

I got it from gastroentorologist. I know he communicated with my neurologist. I am going to see neurologist in January and I will tell him. The medication is pricey: I paid $220 for 30. I am not sure if it crossing bbb. There was publication comparing linzess to motegrity in pwp and linzess has shown even better results.

ncbi.nlm.nih.gov/pmc/articl...

[park_bear in reply to felixned]

The improvement that you are experiencing is evidence that it is crossing the BBB.