Cough medicine drug could stop Parkinson’... - Cure Parkinson's
Cough medicine drug could stop Parkinson’s progression
All of this studies give us hope that science is very close to finally deal with this condition.
This is available on Amazon as Mucosolvan.
True but that is a 30 mg dosage. To equal the dosage used in the study it would require 14 of these tablets 3 times a day.
"We performed a single-center open-label noncontrolled clinical
trial of oral ambroxol therapy (escalating dose to 1.26 g per
day [420 mg 3 times per day]) in patients with PD of moderate
severity."
Oops, that’s a lot of pills!
60mg tablets available as well, but still a lot.
Initial study not randomized or controlled, but worth notice:
jamanetwork.com/journals/ja...
"Mean (SD) scores on part 3 of the Movement Disorders Society Unified
Parkinson Disease Rating Scale decreased (ie, improved) by 6.8 (7.1) points (95%CI, –10.4 to
–3.1; P = .001)."
Some or all of this could be placebo effect. Also this is not new news here – I see that I saved this study in my files in February. No harm in reminding people.
If anyone here has already tried this, please let us know your experience.
en.wikipedia.org/wiki/Ambro...
"Side effects
Field tests to date have not uncovered specific contraindications of ambroxol; however, caution is suggested for patients with gastric ulceration, and usage during the first trimester of pregnancy is not recommended."
Note that this is a bromine compound which is antagonistic towards iodine. Important to be sure you have adequate iodine if you choose to use this.
"Ambroxol has recently been shown to increase activity of the lysosomal enzyme glucocerebrosidase. Because of this it may be a useful therapeutic agent for both Gaucher disease and Parkinson's disease.[13]
It was also recently shown that ambroxol triggers exocytosis of lysosomes by releasing calcium from acidic cellular calcium stores. This occurs by diffusion of ambroxol into lysosomes and lysosomal pH neutralization.[9] This mechanism is most likely responsible for the mucolytic effects of the drug, but may also explain the reported activity in Gaucher and Parkinson's disease.
Both ambroxol and its parent drug bromhexine have been shown to induce autophagy in several cell types"
Nice find, Dap! I just forwarded the link to one of my PD friends as a day brightener and useful information! Thank you!
Art
Not unlike Exenatide, (only safer) this is another 1 of those cases where it is reasonable for us to make a decision to take the stuff now or to wait.
It's already proven to be safe and it looks to me like what is to be gained from waiting for a larger study is if the results of a larger study confirm the results of the smaller study.
If they don't, then it's not effective, then we stopped taking it. If they do, then we will be glad we started when we did to slow or delay for the progression and possibly even to initiate some cleanup a few years sooner than we'd get waiting for FDA approval.
"This study provides us with the 'proof of concept' that we can raise levels of GCase in humans with ambroxol, and that the drug is safe and well tolerated in people with Parkinson's," says Stott.
"Amazingly, after 5 days of ambroxol treatment, levels of alpha-synuclein had decreased significantly (15% on average)."
"Here was a drug that not only re-activated the recycling unit in the cell, but also reduced levels of one of the main proteins associated with Parkinson’s. Ambroxol represented a potential candidate for repurposing."
From Science of Parkinson's;
"What were the results of the study?
"The AiM-PD study used a very high dose of ambroxol (1.26g/day or 21 pills per day) and found that it was well tolerated over the 6 month study. There were no reported serious adverse events due to the treatment during the study. The researchers also reported that the drug was entering the brain, and they recorded a 35% increase in GCase protein levels in the cerebrospinal fluid – this is the liquid surrounding the brain."
"There was a 13% increase in alpha-synuclein concentrations in the cerebrospinal fluid, suggesting that more of this protein was being expelled from cells (via increased exocytosis).
The clinical assessments of the participants suggest that that treatment improved motor features associated with Parkinson’s (a 6.8 point reduction (indicating improvement) in the Movement Disorders Society unified Parkinson disease rating scale (MDS-UPDRS) Part III. Interestingly, these effects were observed in participants with and without GBA1 mutations."
"But as I said above, this study was open label and not designed to evaluated disease modification. It was a very small study with no placebo control group. Thus, any interpretation of the clinical results should be taken with caution.
" -- Simon Stott.
But Simon always says that at the end of every article of anything promising.
scienceofparkinsons.com/202...
I'm inclined to take this stuff.
If you do, let us know how it goes.
I will and if I don't make any other changes at all, perhaps I can attribute any improvement to Ambroxol. (A 15% reduction in a/syn after 5 days sounds pretty good to me -- even if I do have to swallow 42 capsules/day.)
42 capsules a day ? Just thinking about it is hard. Are you planning to ramp up to that dose over a period of time ? Whatever it is, use some caution.
what is the name brand i thought it was liquid
Hi, just wondering if you proceeded with the Abroxol? If you opted not to, may I ask why? Was it based on new research or results?
I did not proceed with Ambroxol.
Hello Marc,
I'm tempted to do the same. How will you decide on the daily dose ?
I don't know. Do you know a reason for not going with the same dose as was used in the study?
That's a lot of pills... It will frighten the pharmacist.
I know that I have this mutation based on participation in genetic testing. I am thinking about taking the pills. Maybe we could get a group together to share results?
Sharon in 3,2,1...
How is it safer than Exenatide (a.k.a., as Bydureon) -- a repurposed drug that has been used by millions of Type II diabetes patients, including myself who took it for five years before going into remission on diabetes? Exenatide is (finally) in third stage trials in UK -- at same dosage as diabetes treatment -- for stopping Parkinson's dead in its tracks. Uniformly successful in earlier trials
[cut-and-paste]
Bydureon, a repurposed Type 2 Diabetes drug is now in third-stage trials in UK for stopping Parkinson’s in its tracks — results expected 2023. Testing — mice, open label, double blind — has been going on for 10 years and it has been positive every time.
scienceofparkinsons.com/201...
According to a very sensitive test, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), 2/3 of Parkinson’s patients are supposed to be insulin resistant. IR may be treated with Bydureon (Exanatide). Just an angle that might get us one step closer to Bydureon.
scienceofparkinsons.com/201...
cureparkinsons.org.uk/news/...
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I have found some symptom relief (don’t have very bad case) with Tumeric & black pepper (pepper makes it bioavailable) — recommended by a doctor.
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I just got off B6 (100mcg) -- which seems to be about the only dose available. Boy did it make a big difference. I ran into the post below on "Journey With Parkinson's. Had to read it four-five times -- by a biochemist.
[quote] I started taking a supplement that had relatively large amounts of complex B vitamins (specifically the one labeled number two below) had 100% (400 mcg) folate, 1667% (100 mcg) vitamin B12 and 5000% (100 mg) of vitamin B6 (based on daily requirement from our diet). Over a period of several days I started feeling stiffer, weaker as if my medicine had stopped treating my Parkinson’s. I especially noticed it one day while playing golf because I had lost significant yardage on my shots, I was breathing heavily, and I was totally out of sync with my golf swing. Just in general, my entire body was not functioning well.
[quote] Over a period of several days I started feeling stiffer, weaker as if my medicine had stopped treating my Parkinson’s.
[quote] The older literature says taking more than 15 mg of vitamin B6 daily could compromise the effectiveness of carbidopa to protect levodopa from being activated in the tissues.
Ambroxol has been known for a while and was available from the Phillipines. My boss's husband who has Gaucher's Disease as well as PD tried it and did not see any progress.
Lots of better info from park_bear.
I tried it. I would still be using it, except I joined a research study and they forbade me to continue it. I did take about 1000mg a day...and that was hard. (As soon as my study is over I plan to go back on it!)
I can't say I saw any positive progress, exactly, but my progression has also been extremely slow, and maybe that can be attributed to the ambroxol? I am over five years in, still don't need dopamine, still mild and one-sided. But I also eat a keto diet, so there's that.
BTW--I do carry a gaucher gene. I guess the ambroxol might be more effective for me? But interestingly, also they say PD progresses more rapidly if you have this gene...which it hasn't for me.
So I like to think something has made a difference.
PS--ambroxol comes in 75mg slow release capsules. The 60mg pills are bitter and awful. If you live in the US you can get it sent from europe. You have to pay an ungodly amount of shipping...but the pills themselves are cheap...TG
My husband is taking the liquid form several times a day. It might not have the potential of 21 pills but is has sure helped his congestion.
I have been taking one 30 mg per day for around a year, with the knowledge that it is not nearly the amount being tested in clinical trials. I was wary of buying from overseas in greater quantities, without a prescription or more evidence. Though I continued taking it as I had read something speculative on a possible benefit of it in opposing viral infection. In any case, after reading this and rereading previous posts, I looked some more to see if there was any other association with calcium. Not that it is necessarily relavent, but I found that an adverse affect in rats are kidney stones according to the study below. Ambroxol is administered by injection in much higher quantity/weight ratio in the rat study, but having recently tested high in Calcium oxalate crystals, it put the fear in me, since I am probably otherwise predisposed to stones. pubmed.ncbi.nlm.nih.gov/175...
KD,
I have a friend who is big on supplements. He got kidney stones three times in a row and each time I suggested Chanca Piedra to effectively eliminate stones that his doctor told him were too large to pass and would require surgery and each time the stones magically disappeared. On the second time I thought he must be taking something that is causing the recurring stones. So I asked him if he was taking a calcium supplement on the third event and he said yes. He was about 72 by the third incident and I told him to stop the calcium supplement as senior men should be able to get enough calcium from their diet without having to supplement. He has not had another incident since stopping the calcium supplement.
Art
It appears that Ambroxol can act against Covid 19 as wellbiorxiv.org/content/10.1101...
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