Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain, Behavior, Heart Disease, Depression, Diabetes, and Neurodegeneration. -- Rhonda Patrick
ATTENTION Broccoli Seed Group (of which I... - Cure Parkinson's
ATTENTION Broccoli Seed Group (of which I am one.) Summation of several studies on Sulforaphane .
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MBAnderson
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•
Fantastic discussion of Sulforaphane by Dr Patrick. I’m starting a jar of broccoli sprouts. Today.
Thank you. Am about to order my jars and seeds 👍
I've not watched all of it, but towards the end it seems to tally with what we are being told by our esteemed Professor Wriga \o/
Great video! Do you consume the broccoli seeds or the sprouts?
I'M about to start seeds
Lots of good info here Marc but my goodness she hardly stopped for breath!
BroccolI seeds arrived Friday btw......just have to figure out a way of measuring them (probably best to invest in a jeweller’s scale I guess) and then I can get started
Yes, she has a lot of good videos and covers a lot of ground in each 1
Marc I had reached out to Albert And was hoping to be part of the group, has he selected everyone?
MBA,
Sulphoraphane is a BACE 1 inhibitor( as a rate limiting enzyme in the production and dispersal of B-amyloid, a key target in limiting the progression of ALZ and late stage PD dementia (lewy body). It is relatively potent in sufficient quantity when sprouted and crosses the BBB (which it needs to do to be effective), and non-competitive (which is very important as well). It is also a precursor to IC3 and DIM.
I doubt it has much affect on MS or PD motor dysfunctions. Generally, among non competitive BACE 1 inhibitors, genistein (as a soy compound) is probably more effective but has specific downsides for males.
Very few cell or pre clinical studies have been done to authenticate its value as an anti-cancer therapy. The cancer cell study I like best was done by Singh et al on human prostate cancer cells looking at SFN inducing ROS resulting in apoptosis. Any You Tube claims beyond that specific "in vivo" claim are exaggerations or bogus.
Broccoli sprouts combined with other cruciferous sprouts are probably the best way to go, but contain only minimal amounts of SFN per cup (on a sandwich or in a smoothie), so overdosing is difficult.
Whether or not BACE 1 inhibitors like SFN are the "final" answer or even truly helpful remains debatable until a lot more credible research is done and published.
Sharon
• in reply tosharoncrayn
I suggest reducing your use of undefined acronyms/abbreviations. If your objective really is to inform, using undefined acronyms with laypeople is not a great way of going about it.
Sharon,
the point of the video is on sulforaphane as nfr2 pathway activator and its consequent antioxidant action. Any of your considerations about it?
Gio
Gio,
Without going into the weeds on NFR2 and its potential chemoprotective properties, ....
..."Despite a near quarter century since the (re)discovery of sulforaphane (Zhang et al., 1992), studies on the pharmacodynamic actions of sulforaphane in humans have been quite limited. This point stands in stark contrast to the many hundreds of publications probing mechanisms of action in cell culture (cell studies) and animal models..."
So, KEAP1-NRF2 signalling based on the literature is basically a constructive and positive cell theory.
However, the Qidong China CT (n=291, 12 weeks) provided some evidence that a broccoli sprout beverage (containing both 40 μmol sulforaphane and 600 μmol glucoraphanin) can modulate the disposition of environmental carcinogens (Chinese dirty smog among other things) and air borne toxins. Whether NFR2 had a primary role in this "modulation" was not determined because the investigators couldn't.
The Chinese study and its results had nothing to do directly with Parkinson's neurodgeneration although I could make the case it did so indirectly a la the "roundup" and "agent orange" pesticide/herbicide theory of PD causation (which may be significant).
Going further, did SFN induce NFR2 signaling in humans in this Chinese human trial and inhibit carcinogenisis? If it did, they couldn't prove it even though I believe they tried.
All claims aside, the efficacy of NFR2 as an meaningful inhibitor of carcinogenisis is still just another cell theory.
If you must gorge yourself on SFN for the hypothetical benefits of NFR2, just eat 2-3 day old broccoli sprouts morning, noon, and night in combination with other veggie spouts out of your Italian window garden. It will change how your hair looks into a multi colored array. (LOL).
Sharon
Thank you Sharon, research may uncover benefits in the future.
I use another way to detoxify myself, even if I like broccoli there is no way I would eat them raw three times a day. LOL 😀
Thank you for the thorough information, Sharon. Albert seems to have corralled about 35 of us and has this ad hoc trial pretty well organized, so I'm expecting some reasonably good information from it.
marc
I hope it works out. Setting up a trial at any level isn't that simple.
Sharon
We all know it will never meet standards, but as a compound that grows in nature, it'll never attract such investments.
MBA,
What is with your excuse? You and Albert don't need the financial backing of Bill Gates to do a modest Phase 1.
You and the other big time movers and shakers on HU can "walk the walk" and donate some of your huge 401-Ks, your pensions and your SSA/disability payments to fund it. Voluntary participation and your donations should cut the bill to no more than $50,000 for a small, well run Phase 1 involving 25-25 participants who volunteer. No need to go over board at this point.
If you can find someone who has done a successful Phase 1 CT to run it, who knows how to get it done on time and budget, you should have no problems completing it and publishing in 12-15 months.
If it pans out, then you and he can start fund raising for the next step.
Sharon
But would having somewhere between 25 participants and 25 participants be enough??
MBA,
Let's avoid playing Dr. Salk here.
#1 25-50 volunteers would be enough for a "simple" Phase 1a. You don't need true design sophistication (randomized intervention, double blinded, n = 150+, multiple cohorts, standardized treatment, etc. ). At this level, diaries and follow up phone/zoom contacts each month would suffice given Covid-19. Therefore, step 1 is to get 25-50 volunteers who will purchase what is needed out of pocket for at least 12 weeks , get a UPDRS before starting, and keep a daily diary.
#2 Forget the 4th grade "chemistry set" stuff. Trying all sorts of chemical mixtures, etc. before hand to determine the "ideal" SFN will ensure a lot of dilly dallying which is almost totally unnecessary and usually ensures doing nothing. Fantasy research goes nowhere.
#3 I would plug in a simple 2 cohort (equal as much as possible by UPDRS scores, drugs taken, and duration of PD) design: 1) a standard extract purchased off of Amazon (purchased by each volunteer or donated) for one cohort versus 2) broccoli sprouts from a local grocery store for the 2nd cohort (MEASURED out for each daily consumption....say 1 cup of 2-3 day old sprouts). Amazon has several choices for online ordering. Very simple to set up.
#3a You could also skip the sprouts (I would not) and simply vary the dose level of the extract for the 2 cohorts.
#4 If participation remained strong, and your cohorts were balanced, you could "cross over" the cohorts after 12 weeks for another 12 weeks if you wanted to observe any differences and the volunteers agreed.
#5 In defining your primary end point, I would avoid a lot of complex testing. I would limit it to a pre/post UPDRS part 3 given preferably by a MD/RN. At worst, by a caretaker. Forget self administration...irrelevant for a CT at any level.
#6 If the findings appear positive, publish your findings as soon as you can in plain English. Send them out to every PD foundation and "pop" medical news outlet. If they aren't positive, do what most clinical trials do who don't meet their primary endpoint. Circular file.
Good luck
Sharon
LOL Then if the results will be very positive someone will buy it and put it in a drawer, because it is not patentable.
Sharon, Good suggestions. Thanks.
What is your opinion of the likelihood of it providing benefit?
Whatever happens with the final results is up to Albert. It's his baby.
Watching the returns tonight with the family.
Glucoraphanin/sulforaphane supplementation probably has some value for slowing the progression of cognitive decline, but this occurs primarily in late stage PD or with ALZ. Whether improvements in PD related cognition would show up in only 12-24 weeks is a long shot.
As far as this idealistic clinical trial you talk about goes, I hope you are finally beginning to understand that a non-drug supplement CT involving PwP are very few for a very good reason. Because no one who has any real expertise in conducting/running a human CT is willingly to work for free, nor do participants want to pay out of their own pocket to participate. Idealism is fine a far as it goes, but it seldom gets the job done.
In closing, Do yourself a big favor.
Ask your girl friend Dr. Rhonda Patrick why she spends her time on Youtube and doesn't do a human CT on glucoraphanin/sulforaphane for PwP. The answer is because she is another cell biologist (doing a lot of MCL-1 cell studies) who doesn't have a clue about conducting a human trial.
Sharon
Often things that help prevent cancer aren't so effective in stopping it once it starts. For example the cyanide compound in almonds seems to help prevent cancer, but research showed that it didn't work for chemotherapy. Probably what happens is your body will convert the cyanide compound into B12 until it doesn't need more, then expel the rest, as long as you don't consume a lethal amount (usually over 50 oz. of raw almonds at once). Thus, it helps if you have a B12 deficiency.
pvw,
With tree nuts, you need at least 2+ cups, 3 TIMES PER WEEK, over a sufficiently long enough period of time to see in my estimation a reduction in mortality or some type of prevention in terms of return...depending on one's type of cancer and, of course, the quality of nuts (no peanuts).
The Yale study was limited to colon cancer, but it was very well done (as expected where n= 800+ over 6 years) using a variety of tree nuts. Are the findings transferable across all types of cancer? I doubt it, but it is possible.
You need to distinguish between bitter and sweet almonds when talking about cyanide. Big difference.
Sharon
I had two colonoscopies with polyps. Each time I had a slow precancerous polyp that normally would take 3 years to have developed cancer. The doctor said once a person had polyps they always had them. I started eating at least 1 oz. of raw sweet almonds a day for at least 5 years, starting before the second colonoscopy. I had no polyps on my last (third) colonoscopy. The doctor didn't say much except schedule another in 5 years.
Note: bitter almonds cannot be legally sold in the U.S. Some countries cook them long enough to reduce the cyanide to a non-lethal level. Bitter almonds are used for almond extract. There are a lot of other things in sweet almonds, such as vitamin E.
Congratulations!
I wasn't aware of the Yale study, but it explains things. It's something to tell the doctor so he's not baffled.
Marc I had reached out to Albert And was hoping to be part of the group, has he selected everyone?
Behold the power cruciferous vegetables -- which I now have to learn to like. Apparently, more powerful than chicken noodle soup.
I'm 74, so back in the 50s when I was growing up and nutrition had not yet come into vogue, (read; nobody knew anything about it) my mother used to cook/boil vegetables until they were mush and therefore of no value and which produced such a unpleasant texture, that I've stayed away from them ever since.
Is my mother to blame for my PD?
Test
Hey looks like I'm not banned anymore . . . go figure.
So . . .
I've been taking 475 mg of Avmacol since February. Avmacol is a blend of sulforaphane glucosinolate and myrosinase which is supposed to aid in the absorption. As part of the research for this post I am now considering switching to Enduracell Plus. Anyways, here are some links with excellent discussions:
eatmovehack.com/best-sulfor...
ncbi.nlm.nih.gov/pmc/articl...
longecity.org/forum/topic/9...
cell-logic-usa.com/dnswexd....
Cooking broccoli dramatically reduces its beneficial effects and bioavailability. So supplement (you might want to add NAC) or use fresh 2-3 day old sprouts or eat it RAW.
Most glucosinolates (per ITCs) appear as glucoraphanin, the glucosinolate of SFN.
Sharon
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