A new study clue finds an understanding approach of PD " The scientists noticed that the PARKIN-lacking neurons with malfunctioning mitochondria had more activation of a protein-making gene called PARIS which is linked to mitochondria regulation.
When Dawson and his colleagues genetically engineered the neurons to remove the PARIS and PARKIN genes—and thus their protein products—the neurons were still able to manufacture new mitochondria and continue—although to a lesser extent—to remove old mitochondria.
Cells with more PARIS activation lose the ability to make new mitochondria and neurons with less PARIS seem to make mitochondria easily, with some—but not total—effect on old mitochondrial removal. Dawson says this seems to indicate that the production of new mitochondria is critical to the maintenance and survival of dopamine neurons. " Study Excerpt
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