Cashew Shell Compound Appears to Mend Damaged Nerves - Neuroscience News.
Summary: Anacardic acid, a compound found in cashew shells, promotes the repair of myelin. The findings could have positive implications for the treatment of diseases, such as multiple sclerosis, that are characterized by demyelination
The study:
Anacardic acid induces IL-33 and promotes remyelination in CNS | PNAS.
I think the title of the thread could be improved by replacing "Damaged Nerves" with "Damaged Myelin Coating of Nerves".
Diosgenin (found in fenugreek) can also increase myelination by promoting maturation of oligodendrocytes:
pubmed.ncbi.nlm.nih.gov/224...
While I don't think PD is a demyelinating disease, MSA is. Does anyone know of LBD is known to involve demyelination?
I drink fenugreek sprout tea since I think I may be in the prodrome of MSA. It seems to help with muscle mass gains from weight training and it makes my sweat smell like maple syrup. If I take too much it causes headaches.
~
Just started looking up HATs. Seems like inhibiting some HATs accelerates aging and mitochondrial damage, but inhibiting others does the opposite.
If I may ask, what makes you think you are "heading" towards MSA? Thank you.
Dysautonomia symptoms, family history (though it is not supposed to be hereditary), and I was deliberately poisoned with rotenone around 30 years ago.
I have had bouts of lower urinary tract symptoms off and on since I was ~ 7 years old (I'm a 52 yr old female). The person who put rotenone in my dinner was a PhD student in limnology with toxicology training; he likely knew about the LUTS since I had confided my health problems to a professor/'mentor' who went on to tell pretty much everyone in the department everything (and that's about as much of that really long awful story that I want to get into).
A few years ago in addition to LUTS I also started having dizziness on standing, really bad constipation, at some point I stopped sweating when I worked out, insomnia, a few episodes of REM sleep behavior disorder, ringing in my ears, etc. - much of the same stuff my father had with MSA (except I'm not sure he had sleep problems).
Last year my daughter suffered an episode of neuroleptic malignant syndrome in response to Reglan. NMS is caused by a sudden drop in dopamine activity and could indicate a genetic problem in the dopaminergic system (NMS is more likely to occur in people with Lewy Body Dementia). I suspect that she is both at risk for developing a synucleinopathy and that the episode itself may have increased her risk further. NMS can result in rhabdomyolysis - did not happen to her, thank goodness - but my father had an otherwise unexplained bout of rhabdo during the course of his MSA (he was not on statins).
Right now I'm not experiencing many symptoms - most seem to have reversed (knock wood). I am taking a large number of (expensive) supplements and am continuing to experiment with various diet/lifestyle interventions (some informed by genetic test results). The big supplements are MitoQ / ubiquinol (got my dizziness on standing under control), PQQ, tributyrin and luteolin. The LUTS is pretty much gone with topical estradiol cream applied directly to the opening of the urethra. I also do the broccoli sprout smoothie thing. So mostly I'm doing okay except I still have really bad insomnia.
I am so sorry for what you have been through. It seems that your therapy/vitamins protocol is working. You have my utmost respect.
Thanks
What could be the cause of restless leg syndrome
Too much C/L
Recording available for NSB4PD webinar with Dr. Sackner-Bernstein on "Why I am optimistic that we might now have a Silver Bullet for PD"
