Mannitol and Treg function

[Rhyothemis]

Someone posted (Art?) that mannitol improves regulatory T cell (Treg) function. At the time I though - no that's mannose - then I did a search and found that indeed mannitol has also been shown to affect Tregs. But now I can't find the article. Does anyone have links to research articles on mannitol and Tregs?

[Hidden]

I do not have the info you are looking for but I have a question. Since you research so deeply I am aiming my question at you. Do you know how mannitol affects the gut microbiome? I know that some "fake" sugars are very bad for the gut microbiome but I can not find anything on mannitol. I am taking mannitol and it has increased my sense of smell (not sure if anything else.) But, I have some trepidation that it may be adversely affecting my gut. I appreciate your time. Thank you.

[Rhyothemis in reply to Hidden]

It probably affects the gut microbiome, but then so does most stuff we eat, and it is difficult to say if the changes would be favorable or unfavorable unless there are some studies, especially one specifically in people with PD. Given the interest in both mannitol and the gut microbiome in PD, you would think there would be one in the works - but research funding doesn't seem to go for the most obvious stuff for some reason.

Just yesterday I ran across an article on high sodium diet causing inflammatory changes in the gut.

horizon-magazine.eu/article...

This just adds to my puzzlement over a study of high salt diet in MSA model mice that showed no increase in rate of progression, though they did have a bit of increase in neuroinflammation. HSD is used in MSA for treatment of orthostatic hypotension, and I had thought that it might contribute to the rapid progression of the disease. I had also thought there was a human study showing no increase in progression in MSA with HSD, but I was mistaken, that was MS - still, you'd think HSD would be bad for that, also - really bad considering it is an autoimmune disease.

jneuroinflammation.biomedce...

It seems like there are so many things going on it is difficult to

predict what the net effect of a substance will be in a particular disease.

We need more studies on OTC supplements and diet, and it seems like the thing to do would be to crowdfund; maybe someone who has organizational, business and people skills (I have none of those) can figure out how to get something like that going.

I keep thinking I want to get some turquoise killifish (they are a natural model for PD) and just run some tests in my kitchen. It won't help for microbiome studies since they are a bit too different, but other stuff. Another idea I had would be to make a kit with easy rearing instructions (if that is possible) and make it available students and teachers so kids could do science projects relating to PD & also raise awareness for PD and other synucleinopathies.

[Hidden in reply to Rhyothemis]

So much for me to respond to! First, yes to crowd funding! It is something I have pondered as well but then what? Beyond my skill set but I am very motivated to be involved just not at the helm.

Regarding mannitol and the gut and why that is not even being looked at; it goes against their interests. As grateful as I am to the professor and his team who discovered this, and I am very grateful, they understandably have no desire to seek out any info in it that could be negative.

I am curious about the cough medicine Ambroxol as well and it’s affect on the gut.

The student test kits is a very interesting idea and could really grow in to something amazing.

So nice to correspond with you and thank you for sharing your ideas and info!

[Hidden in reply to Rhyothemis]

Oh, and the HSD, how did this escape me?! Of course salt is inflammatory and all my efforts to reduce inflammation and salt had not occurred to me. I am very grateful you brought this up!