piRNAs in sporadic PD.

[aspergerian]

Try:

pubmed.ncbi.nlm.nih.gov/299...

OR:

ncbi.nlm.nih.gov/pmc/articl...

OR:

actaneurocomms.biomedcentra...

[aspergerian]

My smartphone presents each of the three links.

(???).

[aspergerian]

Now the study is gone. Withdrawn? Retracted?

[sharoncrayn in reply to aspergerian]

"Sporadic" is lousy term.

Better study --- out of Columbia University, 2012...

Herve Rhinn, Liang Qiang, Toru Yamashita, David Rhee, Ari Zolin, William Vanti, Asa Abeliovich. Alternative α-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology. Nature Communications, 2012; 3: 1084 DOI: 10.1038/ncomms2032

Sharon

[sharoncrayn in reply to sharoncrayn]

"Postmortem pathological analyses of PD patient brain also demonstrate distinctive cytoplasmic protein aggregates (termed Lewy bodies), composed largely of α-synuclein (aSyn), as well as evidence for oxidative stress and mitochondrial dysfunction2"

The key issue in this study and similar ones: Is the notion that similar (albeit unknown) mechanisms may underlie both familial and 'sporadic' PD valid?

The a-syn theory has yet to be proven, or shall we say, it remains unclear as to its true validity.