Switching from Carbidopa Levidopa to Mannitol

[Mjm012649]

So you have to wean off of C/L to start Mannitol?

What dose do you start with?

Which brand of Mannitol is best?

Someone said Walmart carries it. Would it be better to order it else where?

[jeffreyn]

You don't have to wean off C/L to start mannitol. I take both.

The recommended dosage for mannitol depends on weight (too much can cause diarrhea). I'm about 55kg and I take one level tablespoon of mannitol in my coffee every morning. I've not heard of any particular brand being better than the others.

[Mjm012649 in reply to jeffreyn]

Thank you for helping me understand how it is taken. The information you added is informative and teaches so much. It is so nice to be able to ask questions of people who have walked the walk.

[MBAnderson]

You do understand they have 2 different mechanisms of action. Levodopa is a pharmaceutical precursor to dopamine and mannitol is a sugar alcohol that may be beneficial or it may not, whereas most people experience some relief from C/L. You'll want to pay close attention to how you feel after you go off one and on to the other, in other words, to be sure you achieved an improvement.

[Hidden in reply to MBAnderson]

Yes, it seems like an unusual substitution.

[Mjm012649 in reply to MBAnderson]

Thank you for your kind answer. Your explanation was most helpful. I don’t understand a lot about the medications and that is why this forum is so helpful.

[Juliegrace]

Where did you get the idea that you have to wean off c/l to take mannitol? I took both, but no longer take mannitol as I did not perceive any benefit from it.

[Mjm012649 in reply to Juliegrace]

Well, apparently I got the “idea” from what I was reading. I will do more research to try to understand it better. I am new to this all. Thank you for taking the time to respond.

[Jennyjenny2]

You’re not meaning mucuna pruriens (a natural levodopa) in lieu of C/L??

[Mjm012649 in reply to Jennyjenny2]

That was my impression. Having members of this forum take the time to explain it to me has helped me to learn. Sometimes I am hesitant to ask in case I am perceived as an ignorant fool. But than again, I am!

[bassofspades]

why dont you try the mannitol in addition to the CL for a month or two first, then If youre feelin more better, you can see if you want to decrease the CL. Most people notice mild to no improvement on mannitol, however, some people do and all fruit flies do notice remarkable results!

[Mjm012649 in reply to bassofspades]

Thank you for your kind reply, Bass. Some of you folks are such good teachers! How long would you give Mannitol a try before you make a decision on it’s effectiveness?

[bassofspades in reply to Mjm012649]

2 to 3 months at least

[MBAnderson]

Good question. At least a few weeks, but who knows. You might notice a difference in a few days . We have to keep in mind that changes to our diet/nutrition/supplements often take much longer to show results than do pharmaceuticals.

[Mjm012649 in reply to MBAnderson]

Thanks for your reply. What I am understanding is that you take mannitol in addition to C/L. Correct?

[MBAnderson in reply to Mjm012649]

Yes, that's right.

[JakeMax]

Hi Mjm,

Re:Mannitol -

There's a lot of good testimonials online and they've just progressed to a phase 3 trial in Israel(leaders in both mannitol and cbd research).

It's all about the correct dosage, I was advised by an Israeli doctor who also has YOPD.

Her advice 5g twice a day, morning and night working up to 10g twice a day, take with your coffee and use natural ldopa extract from mucuna prunis, they work hand in hand.

Good luck

Jake

[Mjm012649 in reply to JakeMax]

Thank you! What brand do you use?

[JakeMax in reply to Mjm012649]

Pleasure.

I use a company called Blackburn distribution in the Uk.