Neuroprotective effects of mangosteen extracts

[LAJ12345]

I was looking at a product advert by Dr Gundry and noticed mangosteen is a component of his expensive energy product. I love mangosteen but can’t get them in NZ most of the time and found you can buy the extract in bulk so I wondered if there is any research on it for PD and saw there is a study in cells. . I ordered some as I like the fruit so will try adding it to smoothies.

“The present study has, for the first time, demonstrated that alpha-mangostin rescues apoptosis in dopaminergic SH-SY5Y cells treated with MPP+, a cellular model of Parkinson's disease..” ncbi.nlm.nih.gov/pmc/articl...

He also has acerola in his product which I couldn’t find in bulk but tart cherries are also available in bulk from bulksupplements so I bought some of that too. I figure a little bit of these botanicals each day will add variety to the diet.

prohealth.com/library/broad...

[sharoncrayn]

Several studies in mice related to MP or AM and neurodegenerative conditions.

1) "significantly attenuated the cognitive impairment associated with anti-inflammation, increasing BDNF level and decreasing p-tau (phospho-tau S202) in older B6 mice."

Your citation: which compared AM (alpha-mangostin) vs. selegiline showed it to be more effective than selegiline.

2) "post treatment with AM (3 and 6mg/kg) significantly and dose dependently improved the motor deficits and attenuated the oxidative damage indicating decreased rise of LPO and nitrite concentration and restored the decreased activities of endogenous antioxidant enzyme (Glutathione, Catalase, SOD) and mitochondria enzymes (NADPH dehydrogenase, Succinic dehydrogenase and cytochrome oxidase) as compared to selegiline effects."

10 grams of 99.9% purity AM will cost about $125-200 which is obtained by extraction from dried mangosteen pericarps (the husk) with subsequent purification.

Sharon

[LAJ12345 in reply to sharoncrayn]

Thanks. So what % of the dried mangosteen extract would be AM? I just bought this which is more of a food.bulksupplements.com/product...

This is extract of the fruit so hopefully contains the good stuff.

[LAJ12345 in reply to LAJ12345]

Ah, is the pericarp the rind? Maybe not as concentrated in the fruit then?

[sharoncrayn in reply to LAJ12345]

it is the rind or husk, i.e.the outer shell, not the fruit!

[LAJ12345 in reply to sharoncrayn]

Oh well, it will taste nice anyway. Probably has some in it.

[sharoncrayn in reply to LAJ12345]

"what % is AM"?

if it is a "whole fruit" extract, probably very little, although some for sure. the "a" form is more potent than the "b". Don't know why.

Sharon

[LAJ12345 in reply to sharoncrayn]

I can’t see pericarp for sale. The fruit extract is quite cheap and I can afford to throw a few tsp a day into food so if it has some in it it may do something.

Btw have you looked at NZ blackcurrant drinks?

barkers.co.nz/latest-news/h...

[sharoncrayn]

The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia

Best review IMO

[LAJ12345 in reply to sharoncrayn]

Great. Seems worth adding for a try.

[LAJ12345]

res.mdpi.com/d_attachment/n...

Biological Activities and Bioavailability of Mangosteen Xanthones: A Critical Review of the Current Evidence

[LAJ12345]

Distribution of xanthones . The aril is the fruit and pericarp the skin.

Conclusions

13)

The major antioxidants in mangosteen fruit, 􏰀- mangostin and 􏰁 -mangostin, were highly concentrated in the yellow gum which occurred by physiological disorder. The yellow gum and the pericarp of the mangosteen fruit showed much higher antioxidative activity than the aril part in terms of unit weight. The yellow gum of mangosteen might serve as a source of 􏰀-mangostin and 􏰁-mangostin.

tandfonline.com/doi/pdf/10....

[sharoncrayn]

if you can buy it in bulk (the pericarp), worth a try.

Surprised they found it more effective than selegiline. I will have to go back and re-read it.

[LAJ12345 in reply to sharoncrayn]

They talk about the yellow gum too having a high concentration which sounds like is a defect in the fruit I think? Not sure they would sell that. Would that be caused by a fungi or virus in the plant?

Mangosteen (Garcinia mangostana L.)

Gamboge or gummosis is also a physiological disorder characterized by yellow exudation of gum onto the fruit surface

[sharoncrayn]

Follow up on Mangosteen as of Saturday, June 6th, 2020, USA

One of my support group sent over a liquid mix of 1) grapefruit juice, 2) orange juice, and 3) a mixture of mangosteen pericarp powder (not the fruit but the actual rind or husk), mixed red berries mix powder (not sure what was in the mix), and pomegranate fruit powder (one scoop of each).

The taste of the liquid was barely tolerable with the MP somewhat dominant. I would say sour when I tasted the amount he sent over as a dry power mix (see above). If I went with it, I would just try the dry in a mix at 500 mgs. 2-3 times per day to see my stomach tolerance.

The powders were available from Amazon.US. Probably couldn't pass NZ customs.

I have spent some time re-reading parts of the mangosteen studies, but it is a slog.

Sharon.

[LAJ12345 in reply to sharoncrayn]

Thanks Sharon. My mangosteen and tart cherry managed to arrive, much more quickly than expected. It is light brown with a Slightly bitter taste. Not too strong or sour. It’s mangosteen extract but doesn’t say which part, 100% pure, take 1-2 tsp, 3-6 grams per day. At that strength and colour and lack of sweetness I imagine it is whole fruit.

I got it from bulksupplements.com and NZ customs seemed to let it straight through without opening it.

Tart cherry is quite pleasant, red. Sweetish. Take 3/4 tsp per day

[sharoncrayn in reply to LAJ12345]

His MP was NOT bulksupplements.com. Supposedly, the real MP. Don't know if you could take it straight. I will ask him again, but I am pretty sure.

I have pure tart cherry juice (organic-Lakewood brand). Definitely strong. Haven't asked if anyone has the powder I can try. Will check around.

[LAJ12345 in reply to sharoncrayn]

Strong as in has a strong effect or just tastes strong

[LAJ12345 in reply to sharoncrayn]

My thought is that the Japanese eat 30+ foods a day so a small amount of a lot of different foods like these a few times a week add variety to the number of different flavonoids etc eaten rather than as a supplement expecting a noticeable therapeutic effect

So I thought I would try the ones this dr Guidry has in his special formula as a start!

[sharoncrayn in reply to LAJ12345]

I have a couple of people who follow Dr. Gundy and his anti-lectin (plant paradox) diet. I am quite sure that lectins are not the "entire" problem for most people.

[LAJ12345 in reply to sharoncrayn]

Yes, I think it might be like with gluten, some are affected more than others by other lectins. I like Ari Whitten's theory of hormesis that a small amount of anti nutrients and other stressors help the body adapt to stress.