Does high dose thiamine cause constipation?

[Spottedtowhee]

I know that some people have reported that high dose thiamine helps with constipation issues.

I have been gradually increasing my dose weekly having started at 100 mg a day and it seems to be causing constipation. I am currently at 200 mg twice a day.

Has anyone else found that high dose B1 causes constipation?

I am hoping I won’t have to discontinue it.

Thanks!

[M-o-ggy]

It cured mine

[Spottedtowhee in reply to M-o-ggy]

Yes, I’ve heard it can really help.

[Grumpy77]

In my experience thiamine b1 doesn't cause constipation. I had constipation before I started thiamine. A short time after I started thiamine my constipation was greatly reduced. Though it didn't disappear completely

[Spottedtowhee in reply to Grumpy77]

Thanks for your input, Grumpy. It’s great that B1 helped you.

[alexask]

Constipation is a symptom of Parkinson's. I take a level teaspoon of Mannitol, an osmotic diuretic which helps constipation and for some Parkinson's.

[Spottedtowhee in reply to alexask]

Thank you for your reply.

I didn’t have a problem with it before I started B1. I discontinued B1 for a week and the constipation improved. I’m now trying B1 again.

[narcisa56]

I experienced just the opposite - my constipation improved after some time on B1 injections. This was actually the only improvement I observed .................

[Spottedtowhee in reply to narcisa56]

How long before you saw the improvement?

[narcisa56 in reply to Spottedtowhee]

About a month I think...............but due to Corona, I had to stop injections after 3 months and am now taking tablets but my constipation is worse again..........

[Spottedtowhee in reply to narcisa56]

That’s so unfortunate. Hopefully it’s not much longer until you can start injections again.

[narcisa56 in reply to Spottedtowhee]

Thanks Still, I would also like to see some other improvements (tremor,r slowness of movement........) Did you see some improvements in other areas ?

[Spottedtowhee in reply to narcisa56]

I’ve been increasing my dose slowly over the past few weeks starting at 100 mg. Now at 500 mg and haven’t seen any improvement yet. How much are you taking?

[narcisa56 in reply to Spottedtowhee]

300 mg - I am afraid to take more because these tablets contain some calcium and I have kidney stones. Did not look at the label when purchasing them but I do not want to throw them away so this is a compromise. I guess in the long run the dose will be too low...........

[Hidden in reply to narcisa56]

Diagnosed 2012

My regimen:

The positives after B1: no bradykinesia, I cut my food with a knife, no button difficulties, brush my teeth now w/o needing elect brush, more strength. Getting in and out of bed, turning over is easier. No more constipation. Parkinson's progression stopped. Suppressed most motor and non-motor symptoms...

Entering my 8th year post diagnosis and have not fallen, not once, to the surprise of my neuro.

[Spottedtowhee]

Some people find a low-dose works well for them.

[narcisa56 in reply to Spottedtowhee]

Yes, I am aware of that. It is really difficult to find the correct dose without any guidance.

I see you were diagnosed years ago - how have you been coping so far ? I mean medications, supplements, nothing at all?