my neurologist says that whatever I'm doing I'm doing the right thing. keep going like this. According to him I had no deterioration from last year ( don't feel this is true ). He anyway insist ( like last year ) that I start Pramipexole ER ( 1mg ).For your experience how long does it take to this drug to reach efficacy ? immediatelly or after some days ?
Ciao a tutti from Tuscany ( Italy ).
Did you dosage have the following procedure? I assume your 1 mg is 3 times a day. Increasing more slowly is OK and preferred.
Quote:Usual Adult Dose for Parkinson's Disease
Immediate-release:
Initial dose: 0.125 mg orally three times a day
Titration: Increase gradually in small dose increments no more frequently than ever 5 to 7 days
Maintenance dose: 1.5 to 4.5 mg per day based on efficacy and tolerability
Maximum dose: 4.5 mg per day
Comment: The following dose titration was used in clinical trials:
Week 2, 0.25 mg 3 times a day
Week 3, 0.5 mg 3 times a day
Week 4, 0.75 mg 3 times a day
Week 5, 1 mg 3 times a day
Week 6, 1.25 mg 3 times a day
Week 7, 1.5 mg 3 times a day.
-When used in combination with levodopa, the levodopa dose was reduced by an average of 27% from baseline providing a concomitant dose of approximately 800 mg per day.
drugs.com/dosage/pramipexol...
1 Mg total extended release , starting with 0,26 for 10 days then 0,52 and finaly with 1,04 mg. one pill a day.
I worked up to 0.5 mg 3x a day at a much slower pace than the link. Stayed at 0.25 mg for months. Went to 0.375 mg for a month. Then, went to 0.5 mg. For me the side effects diminish over time with usage, thus the gradual increase. I've been taking for less than a year. The purpose of Pramipexole is to decrease your need for L/C. Stopping or reversing the progress of PD has not been verified yet. Have you been doing anything else to stop PD progress?
a lot of exercise, and almost all of the supplements you can think about. After how long you started feeling the effect of pramipexole ?
Just to greet you and congratulate you, I don't use Pramipexolo.
Ciao Luca ,
alle solite, ascoltare tutti e non dar retta a nessuno, ma perchè vai dal neurologo? 
Si scherza,..complimenti !!!
Un saluto dalla Briganzia
Gio
I agree with GioGas, and haven't seen a neurologist for at least 12 years, which puts the responsibility on me to know how to take care of myself, and to be careful to do my own research, before I listen to, or take the advice from others.
Do you take ANY PD meds at all? I am steering clear of C/L. I just take Selegiline. I really admire you.
At bedtime I make a tea from mucuna and green tea powders, and then I find I need to take a C/L about 2 hours later to get me through until morning. I managed to get a standing prescription of C/L with the pharmacist, from a local MD.
I noticed a dramatic difference at 0.375 mg--the starting dose--my smell and taste returned and balance was noticably better. I'm at 1.5 mg and my balance seems to be a bit worse. Hope Mirapex ER works as well for you as it did for me. Paul
Io i dopaminergici non li reggo. Ho provato Requip, poi Neupro e da ultimo Mirapexin, ma tutti e tre mi danno un malessere insopportabile.
Avevo smesso proprio per questa ragione... ma il neurologo insiste che gli dia almeno un mese di tempo. Ora sono a 0,52... ma mi sento molto irrequieto e tendenzialmente violento.. dice poi dopo un pò di giorni passa....
Lucal, I used to get a similar reaction when I took any C/L with any food in my stomach, especially protein, so I learned to only medicate at least 4 hours after eating. When the stomach is in the process of digesting food, it interferes with the absorption of Ldopa. So all that dopamine running loose through the system causes the negative symptoms which you have described.
A Visit From Mr Parkie
How are you doing Compared to last year 
Sharing my experience of having the flu with Parkinson's...
Happy New Year
