Psychedelic drug therapy

[MissRita]

One more! Anyone have any information about psychedelic drug treatment for PD? I’ve been reading about it here and there and there is a lot of research being done on it and I wasn’t sure if anybody in the group had heard about it. Any information would be great! Thx!

[pvw2]

In the 1980's Timothy Leary switched from LSD to virtual reality (VR) because unlike LSD you could control the outcome. Here is a study on PD and VR:

Effects of Virtual Reality Training in Patients With Parkinson's Disease (Parkinson)

clinicaltrials.gov/ct2/show...

[MissRita in reply to pvw2]

Thx!

[Fumaniron]

I imagine it would be a hassle to stop other standard meds for 2 wks? (Sinemet, Azilect) while trying the psychedelic, as I’m not sure of any way to safely do it

[Trixiedee in reply to Fumaniron]

I’ve taken psychedelics on Sinemet with no problems.

[Fumaniron in reply to Trixiedee]

Wow. I was reading warnings with sinemet and Azilect 2 week off period for ayahuasca and Bufo. I imagine similar warnings with shrooms/psilocybin. That’s unfortunate because neuro-regeneration seems very promising (that’s why studies are being done with this) Do u mind telling me which ones your comfortable with, how one doses and the benefits they gave? I understand this would not be medical advice. Thanks so much.

[Trixiedee in reply to Fumaniron]

I have never taken ayahuasca or Bufo. I’m not taking azilect as it made no difference to my symptoms and as it’s an MAO inhibitor I didn’t want to worry about interactions. I’ve taken LSD and psilocybin. I see no reason why sinemet would react with them. I’ve also participated in a San Pedro ceremony while taking Sinemet.

[Fumaniron in reply to Trixiedee]

Thanks. Good to know!

[kaypeeoh]

Ketamine is an older drug that I used for 40 years to anesthetize horses. Recently it has been found to have psychedelic properties. On the black market it's called, "Special K" It's been used on people with depression who were are not responsive to standard drugs.

[38yroldmale]

I have had Ketamine treatments for depression and tried Psilocybin. Hated Psilocybin, got a little much and scared the crap out of me but Ketamine helped with depression. PM if u want to know more.

[silvestrov]

In cases of the atypical parkinsonian syndrome Von Econcomos Encephalitis/encephalitis lethargica in the 1920's doctors used harmine, a component of the plant(s) Bansisteriopsis caapi and Peganum harmala as therapy. Banisteropsis caapi is also 1/2 of the formula in making ayahuasca. What is so interesting about the following article is the videos of VEE patients being injected with harmine.

Banisteriopsis caapi, a Forgotten Potential Therapy for Parkinson's Disease?

"On the opposite side of the world, in the jungles of South America, a concoction (yagé, ayahuasca, or hoasca) prepared from scrapings of Banisteriopsis caapi (B. caapi) liana mixed with leaves of Psychotropa viridis has been used for centuries by the indigenous tribes of the Amazon as an entheogen."

movementdisorders.org/MDS/J...

Banisterosis caapi has MAO inhibitory action and if you are on an MAO inhibitor I would probably skip it if you are already on an MAO inhibitor.

sciencedirect.com/science/a...

[Fumaniron in reply to silvestrov]

Agreed regarding caution with the MAO inhibitor...

[Fumaniron in reply to silvestrov]

silvestrov you always impress me with your breadth of research

[silvestrov in reply to Fumaniron]

Thanks for your kind words. Sorry for the slow reply but now that the New Years is over I have a little more time to do other things since I am not working 2 jobs.

As for learning new information here is a research 'tip'.

When looking for information on the web about a specific Parkinson's disease topic, combine your search 'keywords' such as 'mucuna pruriens', 'Parkinson's disease' with 'NCBI'. NCBI is the National Center for Biotechnology Information and every science study is catalogued at the NCBI. ncbi.nlm.nih.gov/ So when you search the web with 'NCBI' the results include the catalogued science studies (or websites) which reference science studies. It helps to eliminate a lot of blather and focuses the search on legitimate studies.

[Fumaniron in reply to silvestrov]

Excellent!