Nicotinamide Riboside

[Davor1]

Hi, I‘m new here, diagnosed PD in 2013. Does anyone try Nicotinamid Ribosid? What‘s your experience with it?

[LAJ12345]

Hi, my husband has been taking it for about 3 months . He takes quite a lot of things ( see my profile) so I am not sure which of them is helping the most. He is feeling quite good at the moment.

Actually the one thing that has made the most difference over the past 18 months since diagnosis has been Hardy’s daily essential nutrients,

[sunvox]

Most topics of interest have been discussed at great length previously so you will find the search function extremely helpful in that regard. My name is Joe Peck, and I am a frequent poster on this site known for my in depth research and simple explanations. I do not have PD, but another neurological disorder called Spinocerebellar Ataxia Type 1 or SCA1, but I post here in the Parkinson's forum as well as the Ataxia forum because I am a strong believer in one of the general theories of PD namely that the mis-folding of alpha-synuclein (scientifically called oligomerization) is one common root cause in most cases of PD. This is important because mis-folding of proteins is a common issue in many neurological disorders including my own SCA1 as well as other diseases like Alzheimer's and Huntington's.

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Now to your question.

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You will find many people on this site take nicotinamide riboside (known by it's brand name Niagen). You may also be aware that there are 2 clinical trials that are ongoing, one of which is directly for PD:

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A Randomized Controlled Trial of Nicotinamide Supplementation in Early Parkinson's Disease (NOPARK)

clinicaltrials.gov/ct2/show...

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Nicotinamide Riboside and Mitochondrial Biogenesis

clinicaltrials.gov/ct2/show...

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For a thorough discussion of Niagen you might start with this article:

scienceofparkinsons.com/?s=...

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Also, I think you may find the posts of these two gentlemen interesting. They are both managing their PD with their alternative regimens. In particular I recommend clicking on the "Read More" links under MBAnderson's profile:

healthunlocked.com/user/mba...

healthunlocked.com/user/jim...

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and of course I can't help but recommend having a look at what I am doing as I believe it is relevant for Parkinson's as well, and I have stopped my progression for almost 4 years now, and my disease is much faster progressing and 100% fatal so I believe strongly in what I am doing:

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healthunlocked.com/ataxia-u...

healthunlocked.com/user/sunvox

Cheers,

Joe in NY