istradefylline FDA approved August 2019

[Softballman]

Anyone using, knowledge and thoughts. As far as I can tell it’s supposed to add almost an hour to your “on” time. A few years ago that wouldn’t have impressed me but now sounds good.

[park_bear]

ncbi.nlm.nih.gov/pubmed/302...

RESULTS:

"This analysis evaluated 476 patients. Istradefylline was generally well tolerated, despite dyskinesia and hallucination being the most common ADRs. Reduction in off-time was observed in 38.2% of patients, off-time symptoms were improved or markedly improved in 44.7%, and motor dysfunction was improved or markedly improved in 48.5%. The mean UPDRS Part III score decreased from 33.7 to 30.3 at the end of the study. The physician's global assessment rated the drug as effective in 61.3% of patients."

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So it might be helpful. If you decide to try it be alert to the potential adverse effects.

It is related to caffeine, and functions in a similar way. So, coffee might work just as well.

See a discussion of coffee and Parkinson's here:

healthunlocked.com/parkinso...

[Softballman in reply to park_bear]

CYP3A4 I think that’s the culprit