Effects of Levodopa on progresssion of PD

[Farooqji]

ncbi.nlm.nih.gov/pubmed/155...

[Xenos]

Hi Iqbaliqbal, the paper is dated December 2004. AFAIK, other studies found that L-Dopa had no effect on PD progression.

[WinnieThePoo]

2004. Is this nostalgia month?

[Farooqji in reply to WinnieThePoo]

Science never gets old

[WinnieThePoo in reply to Farooqji]

But it doesn't stand still either. There has been new research in this field which revises these conclusions

[Farooqji in reply to WinnieThePoo]

Can you please share those new findingsite. Thanks in advance

[WinnieThePoo in reply to Farooqji]

nejm.org/doi/full/10.1056/N...

or here jwatch.org/na48306/2019/01/...

medscape.com/viewarticle/83...

[Farooqji in reply to WinnieThePoo]

Thanks

[reedboat2]

The results were inconclusive, but "the neuroimaging data suggest either that levodopa accelerates the loss of nigrostriatal dopamine nerve terminals or that its pharmacologic effects modify the dopamine transporter". That doesn't sound too good - JG