A new trial : Study of UB-312 in Healthy Participants and Parkinson's Disease Patients

[Farooqji]

clinicaltrials.gov/ct2/show...

[ghoegap]

hello! For the longest time I have wanted to say thank you for posting the Joe Dispenza book! So much appreciated !

[gaga1958]

looks like its only at Netherlands ?

[sharoncrayn]

A peptide vaccine?

Interesting how they see both as co-equal since all peptides (for the most part), are usually never categorized as vaccines because they are not made from germs. They are "linked" amino acids (in multiples) with a covalent bond; they are not formed by germs.

From the recruitment of participants page:..."peptide-based vaccine ... may provide an active immunotherapy option for treating synucleinopathies including the most prevalent form, PD."

The excessive (to an extreme) accumulation of alpha-synuclein (a insoluble brain protein) in the neurons include Parkinson disease, dementia with Lewy bodies (predominate in PD as the PD dementia form), and multiple system atrophy (some rare diseases).

This excessive accumulation is NOT a prion like process or nor does it result in a prion structure. Further, prion diseases are generally not categorized as neurodegenerative because they are deemed to be "infectious". PD has never been proven to be an infectious disease even in the form of its dementia.

[MarionP in reply to sharoncrayn]

You are right, it is odd that a peptide route should be characterized as vaccine, vaccine is usually referred to in the case of the cause and intervention point being biologicals.

However, plenty of folks consider and treat prions as if they might be biologicals, because in some respects they act that way...such as the spongiform encephalopathies (mad cow (called BSE), its variants in several other species (e.g., deer, and humans' Creutzfeld-Jakob disease). Prions are mis-shaped or mis-folded proteins, which is what alpha-synuclein is...and for some reason they appear to sometimes follow an infectious behavior route, as in when they move or stimulate propagation from gut along vagus nerve into brain, without yet knowing whether that is by biological reproduction or some process that causes extant cells to mis-fold themselves) perhaps that has some relation to why they used the word vaccine, neither term fits very perfectly. Perhaps they are thinking of a virus-like intervention that prevents, thus "vaccine."

[sharoncrayn in reply to MarionP]

mp:

"Prions are mis-shaped or mis-folded proteins, which is what alpha-synuclein is..."

I don't see them as identical.

They (prions) are almost always seen in infectious models of this type of disease. I don't believe any study as shown them to occur outside of that model. Perhaps you know something that I don't.

The prion hypothesis simply doesn't apply to PD if the two current studies are relevant and valid. We see nothing in the literature to suggest PD is an infection, although it all depends on how you define your terms. (was Roundup and gly... an infection of one's brain?)

Vaccines carry some negative connotations in various research studies, so perhaps they are covering their public relations bases with this peptide-vaccine hypothetical combination.

[MarionP in reply to sharoncrayn]

If you can manage to tell me what the people who chose their peculiar nomenclature were thinking when they said "vaccine." Then we'll both know. Meanwhile, prions aren't miss-shaped proteins, but all alpha synucleins in PD and dementia certainly seem to be...are they the disease, or their unremoved accumulation and presence? And at least, infection-like (I don't know, vaccine isn't my word) alpha synucleins misfolded have been shown to take a path that at least at the moment appears to mimic some infections, (or their action has, if not actual AS proteins, it's not yet well defined what specifically results in the large proliferation of AS misfoldings in the brain, they can't all be migrating from the gut, that would seem to be too many, the vagus nerve is not a large enough pathway to be transporting all those cells...) but maybe something about the misfold-eds is transported, perhaps some trigger instruction of effect of cell programming that is transferred, whether nucleic or some cleaved rna/dna instruction segment or maybe a process that creates a mutation or deletion or whatever, epi-instruction to create cell death or just kill some critical chain, or trigger programmed cell death, nobody knows just yet, it is really super early).

But I do know that there seem to be enough variant factors in PD that there are numerous routes to the PD symptom complex. Some are genetic and others not so much, some seem to be respondent to industrial pollutants introduced into human tissue and others less so...many cofactors are possible and a lot of them have evidence as coincident contributors, if not outright cause. Then there are the flu/virus infections specifically shown to have killed off wholesale swaths of cells in substanta nigra and other regions, I believe there are least a handful of studies making the link.

Tomato, tom(ah)to, let's call the whole thing off.

[MarionP in reply to sharoncrayn]

Prions are mis-shaped or mis-folded proteins

I stated this in error; prions are not mis-shaped. My error.

[sharoncrayn in reply to MarionP]

Is PD another BLV (bovine) infection of milk situation with female breast cancer where a percentage of PD patients come from an environmental infection? Which creates prion structures in the brain stem?

Need many more autopsies to prove or disprove. I don't think so because previous autopsy studies of PD brains showed LB damage, not prion damage.

They are different.

[CPT_Helen Partner]

V