We all wrack our brains trying to figure out how we wound up with Parkinson's. Well water? Mercury toxicity? Lead paint? Roundup? Too much LSD in the 60s?
The other day I was talking about my condition with my mom, and she asked me if Parkinson's disease is hereditary. I said it can be, but no one else in our family has it. Well then she mentioned that her aunt once told her that her father (my grandfather), who died at the age of 37, when my mom was 11, used to have very shaky hands. But her aunt thought it was from drinking alcohol. But he didnt drink more than a beer or two each day.
Aha!
By the way, he died of a subarachnoid hemorrhage at 37. My mom hardly knew him, he worked 2 jobs and went to school too.
I wonder if there would be any benefit to genetic testing ?
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bassofspades
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My father had a lot of my problems, weak legs, poor balance, slight hand tremor, he was never dg with Parkinson it, I often wonder if he had it. He passed away aged 84.
My hubby went to a natural doctor and they ordered tests from 23 and me and ancestry .com. Then she had opus23 reports run on them to analyse them. Is it possible to send files on this site? I would be happy to forward his one to you to look at to see whether you think it can be helpful for you to get the same tests. Maybe message me your email if you like.
I think the opus report can only be ordered by a qualified person as you need someone to go through the results with. Actually you probably don’t but some people would to understand it so I don’t think you can order that for yourself.
I have discovered he has a very nasty combo which wipes out practically all his dopamine pathways completely or partially, and also his seratonin ones.
Also vitamins d and b pathways. He doesn’t know the full extent of it as I think he might give up. I’m a bit worried for my kids actually too. He isn’t interested in investigating so I do it. Are you sure you want to know the worst? He has high dopamine beta hydroxylase activity which the report states “outcome bad”.
A study found that adenosyl B-12 is helpful for the carriers of the LRRK2 mutation. So this is one reason why it is helpful to get tested. There also a couple of pharmaceutical drugs in development to treat Parkinson's due to this mutation as well.
Hi Bass of Spades, in Dr Perlmutter's current series on Alzheimer's, he says that we are not tied to our DNA. We can largely break free of our genetic inheritance by correct eating and our lifestyle generally. Sally's diet, given above, is helpful. All of us need to avoid packaged foods and added chemicals; also sugar. Good are low carbs, high good fats (coconut, avocado and olive oil) and lots of fresh vegetables.
I get your point, BofS. Dr Permutter always talks of AD in his family and how he has not allowed it to happen to him. He focuses on prevention. Dr Bredesen talks about reversal in some cases. He has achieved some remarkable successes with AD sufferers. Having said that, I was able to reverse my husband's AD using the advice of these doctors but I obviously and sadly I couldn't do anything about his PD.
I am under the impression that about 10% of Pd cases are hereditary. I would imagine that everybody who has Pd must have the necessary genes to allow Pd to happen. Am I wrong in my thinking?
23 and Me, combined with the Fox Foundation Insight studies, included me in retrieving a specimen, for DNA genetic testing. The results stated that I did not have any genetic variants, of the genes for Parkinson's studied, in my DNA. I am very pleased that I did the genetic testing! I get up to date reports every few months, from 23 and Me. I still participate with Fox Insight, and contribute info. to them, by answering questions, on a regular basis. Knowing results of DNA testing can be very beneficial, in more ways than one. I got some surprises, both good and not so good, when I got the DNA results. Basically, I was pleased with the findings.
Bass, I would definitely recommend genetic testing. Get the raw file from 23andme or AncestoryDNA and upload the raw file( your whole genome) to Dr Ben Lynch site for $45 and get the results instantly.
I also strongly recommend reading “Dirty Genes” book from Dr Lynch after you get the analysis report.
Many of us has issues with Methylation which is related to Mthfr and other issues related to Genes like MAO A , MAO B or COMT. “These genes can be cleaned with lifestyle changes”, Dr Lynch says.
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