Sinemet after 20 minutes

[DougV]

I wonder if anyone else experiences this. About 20-30 minutes after I take sinemet my tremors get worse for a few minutes, and then calm down.

[park_bear]

I bet you are taking the immediate release version. It gives you a burst of levodopa which is then converted to dopamine. The CR, controlled-release, version provides more steady flow.

[PDman1 in reply to park_bear]

You’re right, it’s not the CR kind. But why does a burst of levodopa cause tremors?

[park_bear in reply to PDman1]

For me, immediate release C/L caused a jerky twitching, otherwise known as dyskinesia. Not exactly tremors, but could be labeled as such if a person did not know the difference. Is what you experience dyskinesia, or tremor just like your Parkinson's symptoms?

[Ep0522 in reply to park_bear]

For me it’s just like my tremors. Told my neurologist, but he passed it off as being psychological.

[PDman1 in reply to park_bear]

It’s generally similar to my tremors, but a bit more intense,

[Ep0522 in reply to PDman1]

It does the same to me, but lasts more like 30 minutes.

[Juliegrace]

Yes, I believe it's due to the initial "rush" of dopamine then it evens out.

[Joycex]

Yes same with my granny but doesn’t calm down until she eats something

[LAJ12345]

Try having it on an empty stomach and not eating or taking other supplements for 20-30 minutes. If it still does it try taking a uridine capsule at the same time. My husband takes the Jarrow one . I am not sure how much it helps or whether it is waiting for food but he doesn’t seem to have the same reaction now.

vitacost.com/productResults...

[bcowart]

yes. Same thing for me but it's more like I have to wait an hour before that happens. It's crazy 5 minutes and I wail and curse the stars. Then the relief comes in on little cats' feet/

[SELFMeder]

I don’t experience the immediate tremor, but I often get a minor sick stomach with the first, morning pill. Food often helps.

[Hidden]

I get that too. I figure it has to get worse before it gets better and just deAl with it as a side affect.