High B12 & PD?

[DadWithPD]

My dad is awaiting confirmation of PD but was told he has it. Symptom is hand tremor.. not shaky..different. They called to tell him to stop taking B12 supplement because his levels are high. He does not take B12 or any other medication/vitamins/ect. Has anyone with PD had this issue or know what this might be about? It is only 840 and I've read 200-900 can be normal but doctor/nurse said it is 4x normal??

[Hidden]

Here is an article on some potential reasons for high B-12 readings:

b12-vitamin.com/blood-levels/

Art

[DadWithPD in reply to Hidden]

Thank You

[jimcaster]

I always thought PwP were low on B12 and other B vitamins and therefore had high homocysteine levels, which is bad. I take a lot of B vitamins every day, including B12.

ncbi.nlm.nih.gov/pubmed/115...

[DadWithPD in reply to jimcaster]

Thats what I reasoned as well. So probably unrelated....

Thank You

[MBAnderson]

Whew. I thought I was the only one. I had a blood panel recently and mine was high and I, too, don't take B12 supplements. If his levels truly are high, which a blood test can get wrong, it might mean his body isn’t utilizing it correctly and it’s accumulating.

He should have MMA urine test.

"... B12 can thus show up in high levels during a serum test, but have no biological function whatsoever."

All things being equal, I’d worry more about a deficiency and probably all PWP are deficient except those who have intentionally intervened to correct it.

nutritionfacts.org/video/ne...

PS. 840 is not high.

[Astra7]

B vitamins can make you anxious and shaky. Apparently they need to be in balance with each other. He may be lucky and have been misdiagnosed- 40% of people are. Fingers crossed.

[DadWithPD in reply to Astra7]

I am hoping it might mean there is something else wrong rather than PD. Impossible to know without more tests ect. Thank You I am hoping he might be in that 40%

[mmnucmed01 in reply to Astra7]

Do a Dat scan and find out for sure ?

[BUZZ1397]

I would do a little research such as what you’re doing posting to this bulletin board good idea to get a second opinion maybe from another doctor A neurologist who specializes in autoimmune disease

[camper1]

800 is within range, the range is 200 to 900 on lab slip but has a disclaimer that anything under 450 (as I remember) can cause neurological damage. I am b12 deficient and have taken b12 injections and have lab values of 1,200.

[LAJ12345]

Maybe everyone else is deficient hence the “normal” range.

[Tempest22]

I don't have PD, but started taking B-1 because I have irritable bowel syndrome and or ulcers. I have had a tremor for years, but it became in noticeable when I started taking L-Carnosine because I resdvitvwould help me stay awake while driving. Then when I started taking 1500 mg B-1 every morning and 500 mg my tremor is usually non existent. I did have a little this morning while I was fixing breakfast, but after I took 3 500 mg capsules , the tremor dissapeared. I am also taking 3 to 4 grams of no flush Niacin ( buffered with inositol) which I take for other reasons.

[Hidden in reply to Tempest22]

Dr. C has two cases of essential tremor that were helped by B-1, so that makes sense.

Art

[mmnucmed01]

How is the confirmation to be made? Did he have a Dat scan?

[JAS9]

Here's a 9 min video that explains methylation and what happens if it's not functioning properly. I think this could be one reason that B12 levels can be high, although frankly I can't quite follow it well enough to be sure. Anyone care to give it a go?

youtu.be/3k96NQ0N4cQ(Not working as expected?)