Tryptophan & Niacin(B3) Relationships

[Kia17]

“Your body needs essential nutrients in regular amounts in order to continue to function properly. Of these, the amino acid tryptophan and the vitamin niacin share a special link. These two nutrients have different properties and fulfill very specific roles in your body’s biochemical processes. In addition, a deficiency in either one of these chemicals can lead to negative health effects.”

livestrong.com/article/4293...

[bassofspades]

The 5-htp form of tryptophan is a direct pterosaur of serotonin.

[Kia17 in reply to bassofspades]

Bass,

How much 5-Htp have you been taking? I think it’s a part of your amino acids programme?

As far as I know, the 5-htp and SSRIs reduce the amount of Dopamine. Any thoughts?

[bassofspades in reply to Kia17]

I take a total of 150mg 5htp per day divided into two doses. Yes serotonin competes with dopamine for amino acid precursors, according to Hinz, but somehow his protocol, with the various cofactors, balances it out. Probably with tyrosine. Hinz has a paper on the competitive inhibition theory that explains it. Its easy to find on Google. Edit: see link in reply

I wouldn't take an SSRI because that doesn't solve the underlying problem (depression anxiety caused by deeper subconscious issues). The symptoms it "cures " will reappear in another form, according to Dr John Sarno.

[Kia17 in reply to bassofspades]

Thank you Bass

[bassofspades in reply to bassofspades]

ncbi.nlm.nih.gov/pmc/articl...

Everyone with pd should read this.

[LAJ12345 in reply to bassofspades]

Thanks. That is so interesting. How long / how many rounds of testing did it take to settle on what amino acids you should take? Does the dose stay constant once you have found the right level or is it constantly changing?

It sounds like it isn’t a good idea to take the c/l or even the mucuna without knowing how much of the other precursors to take.

[bassofspades in reply to LAJ12345]

For me, we used what is called the pill stop method to test for the proper dose. We got it in 3 weeks and im still on the same dose since then. Its been 13 months. Recently i was feeling so well that I tried to reduce the amount by 1/3 but my symptoms came back within a week.

Unfortunately the dr that set me up recently passed away. He saw me twice in the office then we did the rest over the phone.

[Kia17 in reply to bassofspades]

Bass,

Please can you share with us the cost of your Amino Acids treatment?

Thank you

[bassofspades in reply to Kia17]

Sure.

Neuro replete 2 per day $29 for a bottle of 60 pills. $15/ month

Mucuna 6 pills per day $18 per bottle of 120 pills $27 per month.

Cysteine 6 pills per day $18 per bottle of 250 pills $13 per month

$55 per month total.

It is my understanding that I am on a lower than average dose.

[KERRINGTON in reply to bassofspades]

Hello, do you think these supplements enhance the thiamine protocol, and which strength mucuna are you on ?

Thanks

[bassofspades in reply to KERRINGTON]

166mg mucuna yielding 100mg L-dopa per capsule. I take thiamine too, 3000mg per day and i would say my aminos do the majority of the therapy but the thiamine helps very much as well.

I started with a UPDRS score of low 30s. Amino acids took it down to low 20s. Thiamine took it down to mid teens. Now i am treating myself for TMS tension myoneural syndrome, and this therapy has taken my score all the way down to about a 3. The therapy involves reading books by Dr John Sarno and working out my subconscious "rage" through journaling. Had i known about tms when this all began, i think i never would have gotten pd. I know that is a strong statement but if you learn about it you will understand. And if your PD is of idiopathic origin and came on suddenly with no known cause, then you may benefit from this as well. Once i hammer out the details in my head I will post a nice detailed post on this. I have touched on it over the past week. I will say in addition that serotonin is involved as well, according to what I am learning

[Kia17 in reply to bassofspades]

Bass,

Have a look on this link;

curablehealth.com also can get it on App Store too.

Its based on Dr Sarno’s theory.I got free version and now signed up for a monthly subscription. It looks a very good app.

[bassofspades in reply to Kia17]

I actually tried that app just last night. I didn't like it. The book is all you need. The divided mind by John Sarno. And Nicole Sachs' YouTube videos. I might get her book too.

[Kia17 in reply to bassofspades]

Thanks for your input.

[LAJ12345 in reply to bassofspades]

thanks for all this information. I am finding it most useful.

[Kia17 in reply to bassofspades]

Many thanks Bass

[bassofspades in reply to Kia17]

Thank you too my good friend!

[Hidden in reply to bassofspades]

How do you factor diet into your supplementation regime? Diet is presumably not a constant.

[bassofspades in reply to Hidden]

Go as much organic and paleo as you can. Low carb as best as you can too. Nobody's perfect but do your best. Timing of proteins and meds does not matter. Intermittent fasting is a good way to go too.

[Hidden in reply to bassofspades]

So you may be supplementing when you could get diet to relieve that burden or when it is already supplying your needs. Organic, paleo and low carb is also a combined dietary burden. If you are not carrying excess body fat there is also the issue of taking onboard sufficient food groups so as to provide for ketosis without attacking the body’s musculature.

[MBAnderson in reply to Hidden]

Would you please elaborate some on this?

Is low-carb a dietary burden?

Are you saying we can be in ketosis without low-carb?

[bassofspades in reply to Hidden]

Osidge im not sure i understand what you're saying.

[Niggs in reply to bassofspades]

Sorry if I sound like a stuck record, but I thought I'd mention again I get the same 'very negative' reaction to too much agonist 'and' any serotonin supplementation whether ssri or 5-htp which is in line with Swedish research suggesting anxiety is caused by too much not too little serotonin.

This in my experience confirms a dop/ser relationship and possibly the reason stress makes pd so much worse and why so many of us were dx'd after chronic high level stress,

perhaps we just needed a reduction in serotonin but instead were put on the dopamine treadmill.

[Kia17]

Fluoxetine Administration Exacerbates Oral Tremor and Striatal Dopamine Depletion in a Rodent Pharmacological Model of Parkinsonism

nature.com/articles/npp2015...

[JANVAN]

Thanks !!

Do you know a good branch of niciosamide riboside ??

[Kia17]

Janvan,

I personally take Tru Niagen from ChromaDex